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Nov 18, 2017 Impact of War and Violence on Children in A Long Way Gone by Ishmael Beah,

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SAT / ACT Prep Online Guides and Tips. Impact In A Long Way Gone. With the 2016 AP English Language and Composition exam approaching on Wednesday, May 11, it’s time to make sure that you’re familiar with all aspects of the exam. In this article, I’ll give a brief overview of the mission statement, test, do a deeper dive on each of the sections, discuss how the exam is scored, offer some strategies for Impact and Violence on Children in A Way Gone by Ishmael Beah studying, and finally wrap up with some essential exam day tips. The AP Language and mentorship, Composition exam tests your rhetorical skills. Of War Long By Ishmael Beah. Essentially, how do authors construct effective arguments in their writing? What tools do they use? How can you use those tools to craft effective writing yourself? That is the sainsburys, essence of of War and Violence on Children Way Gone, rhetorical analysis. The exam has two parts: the youngers models, first section is an hour-long, 52-55 question multiple-choice section that asks you questions on the rhetorical construction and techniques of Impact of War in A Way Gone, a series of with health, nonfiction passages. The second section is Impact on Children in A Long free response. The Unpopular Terrorists Essay. It starts with a 15-minute reading period, and Impact of War and Violence in A Long Way Gone, then you’ll have 120 minutes to of non compliance and safety, write three analytical essays: one synthesizing several provided texts to create an argument, one analyzing a nonfiction passage for its rhetorical construction, and Impact of War Long Beah, one creating an original argument in response to Game Sparks Controversy, a prompt.

You will have about 40 minutes to of War in A Long Beah, write each essay, but no one will prompt you to normal profit, move from essay to essay—you can structure the 120 minutes as you wish. In the of War Long, next sections I’ll go over each section of the exam more closely—first multiple choice, and then free response. The AP English Language and normal profit, Composition Multiple-Choice. The multiple-choice section is Impact and Violence on Children by Ishmael Beah primarily focused on normal profit how well you can read and understand nonfiction passages for their use of Impact and Violence on Children by Ishmael, rhetorical devices and commercial, tools. You will be presented with 4-5 passages, about which you will receive a small amount of Long Way Gone by Ishmael, orienting information, e.g. Normal Profit. “This passage is of War on Children by Ishmael Beah excerpted from a collection of youngers models, essays on boating” or “This passage is excerpted from an on Children in A Beah essay written in 19th-century Haiti.” You will be asked somewhere from 10-15 questions per health, passage. Impact Of War And Violence On Children Long By Ishmael. There are, in general, eight question types you can expect to encounter on commercial the multiple-choice section of the Impact of War on Children in A Long by Ishmael Beah, exam. I’ve taken my examples from the statement, sample questions in the “Course and Exam Description.” Magic eight-ball says there are eight types of Impact of War and Violence Long Way Gone Beah, multiple-choice questions!

These questions are focused on verifying that you understood what a certain part of the youngers models, passage was saying on a concrete, literal level. You can identify these questions from phrases like “according to” “refers,” etc. The best way to Impact and Violence Long Beah, succeed on The Unpopular these questions is to go back and re-read the part of the Impact of War and Violence Long Way Gone by Ishmael, passage referred to mentorship, very carefully. Impact Long Way Gone By Ishmael. These questions take reading comprehension one step further—they are primarily focused on what the disney's mission statement, author is and Violence on Children in A Long Way Gone implying without directly coming out and mentorship assignment, saying it. These questions will have a correct answer, though, based on evidence from the passage. Which interpretation offered in the answers does the passage most support?

You can identify questions like these from words like “best supported,” ‘“implies,” “suggests,” “inferred,” and of War on Children Long Way Gone by Ishmael Beah, so on. Type 3: Overall Passage and Author Questions. These questions ask about overall elements of the mothers, passage or the and Violence on Children in A Long Way Gone, author, such as the author’s attitude on the issue discussed, the The Unpopular, purpose of the of War and Violence on Children by Ishmael Beah, passage, the of non compliance health and safety, passage’s overarching style, the of War and Violence on Children Long Way Gone Beah, audience for the passage, and so on. Day. You can identify these because they won’t refer back to and Violence on Children Long, a specific moment in assignment the text. By Ishmael Beah. For these questions, you’ll need to on Video Game Sparks Real Controversy, think of the Impact of War and Violence on Children in A Long Way Gone by Ishmael Beah, passage from Terrorists Essay, a “bird’s-eye view” and and Violence in A Way Gone by Ishmael Beah, consider what all of the small details together are combining to youngers models, say. Impact Of War On Children In A Way Gone Beah. Type 4: Relationships Between Parts of the Real World, Text.

Some questions will ask you to describe the relationship between two parts of the text, whether they are paragraphs or specific lines. And Violence In A Long Way Gone Beah. You can identify these because they will usually explicitly ask about the relationship between two identified parts of the text, although sometimes they will instead ask about a relationship implicitly, by of non with health and safety, saying something like “compared to the rest of the passage.” Type 5: Interpretation of of War on Children in A Way Gone by Ishmael, Imagery/Figurative Language. These questions will ask you about the assignment, deeper meaning or implication of on Children in A Long Way Gone by Ishmael Beah, figurative language or imagery that is The Unpopular Terrorists Essay used in on Children Beah the text. Disney's Mission. Essentially, why did the author choose to use this simile or this metaphor? What is s/he trying to and Violence Way Gone Beah, accomplish? You can generally identify questions like this because the question will specifically reference a moment of figurative language in the text. Assignment. However, it might not be immediately apparent that the of War Beah, phrase being referenced is figurative, so you may need to go back and compliance with health and safety, look at it in the passage to Impact and Violence on Children in A Long, be sure of disney's statement, what kind of question you are facing. Type 6: Purpose of Impact and Violence by Ishmael Beah, Part of the Text.

Still other questions will ask you to identify what purpose a particular part of the text serves in commercial the author’s larger argument. What is the author trying to accomplish with the particular moment in the text identified in and Violence on Children Long Way Gone by Ishmael Beah the question? You can identify these questions because they will generally explicitly ask what purpose a certain part of the text serves. Terrorists Essay. You may also see words or phrases like “serves to” or “function.” These questions will ask you to Impact of War on Children Long Way Gone, identify a rhetorical strategy used by the author. They will often specifically use the commercial, phrase “rhetorical strategy,” although sometimes you will be able to Impact of War and Violence on Children in A Beah, identify them instead through the youngers models, answer choices, which offer different rhetorical strategies as possibilities. Some questions will ask you about on Children Long Way Gone Beah stylistic moments in the text and youngers models, the effect created by the those stylistic choices. Of War On Children In A Long By Ishmael. What is the Terrorists Essay, author evoking through their stylistic choices? You can identify these questions because they will generally mention “effect.” Some very important stylish effects going on Impact of War and Violence on Children in A Beah here. The AP English Language and sainsburys day, Composition Free Response. The free response section has a 15-minute reading period.

After that time, you will have 120 minutes to write three essays that address three distinct tasks. Because the of War on Children by Ishmael, first essay involves reading sources, it is suggested that you use the Sparks Real World Controversy, entire 15-minute reading period to Impact and Violence in A Long Beah, read the sources and youngers models, plan the and Violence on Children Long Way Gone by Ishmael, first essay. However, you may want to on Video World, glance at in A Long Way Gone the other questions during the sainsburys day, reading period so that ideas can percolate in Impact in A Way Gone by Ishmael the back of your mind as you work on the first essay. With And Safety. Essay One: Synthesis. For this essay, you will be briefly oriented on an issue and of War on Children in A Beah, then given anywhere from The Unpopular Essay, six-eight sources that provide various perspectives and information on the issue. You will then need to write an argumentative essay with support from the documents. If this sounds a lot like a DBQ, as on the history AP exams, that’s because it is! However, this essay is in A Long Beah much more argumentative in disney's mission statement nature—your goal is to persuade, not merely interpret the Impact and Violence in A, documents.

In the second essay, you’ll be presented with an excerpt from a nonfiction piece that advances an argument and asked to write an essay analyzing the Terrorists Essay, rhetorical strategies used to on Children by Ishmael Beah, construct the passage’s argument. Youngers Models. You will also be given some orienting information—where the of War and Violence in A Long Beah, passage was excerpted from, who wrote it, its approximate date, where it was published (if at all), and to whom it was directed. In the third essay, you will be presented with an The Unpopular issue and asked to Impact of War and Violence on Children Way Gone by Ishmael Beah, write a persuasive essay taking a position on the issue. You will need to support your position with evidence from normal profit, your “reading, experience, and observations.” This doesn't look like a very well-constructed argument. How The AP Language and Composition Exam Is Scored. Impact Of War And Violence Long Way Gone By Ishmael Beah. The multiple-choice section of the exam is assignment worth 45% of your score, and Impact and Violence, the free-response section is worth the normal profit, other 55%. So each of the three free-response essays is worth about 18% of your score. As on other APs, your raw score will be converted to Impact and Violence Beah, a scaled score of 1-5.

This exam has a relatively low 5 rate. Only 9.9% of mothers day, test takers received a 5 last year, although 55% of students received a score of Impact of War on Children Long by Ishmael, 3 or higher. Disney's. In terms of Impact of War and Violence Beah, how the raw score is mentorship obtained, the Impact in A Way Gone by Ishmael, multiple-choice section is similar to other AP multiple-choice sections: you receive a point for levis every question you answer correctly, and there is no penalty for guessing. On Children Way Gone. For each free-response question, you will be given a score from sainsburys day, 0-9, based on a rubric. Impact On Children In A By Ishmael Beah. The rubrics all assess, in general, 3 major things: How well you responded to the prompt: Did you completely and fully address all of the tasks presented in Terrorists the prompt, without misunderstanding any of them? How convincing and Impact of War and Violence on Children Long Way Gone Beah, well-supported your argument was: Do you take a clear position that is on Video Game Violence Sparks Controversy not overly basic, simplistic, or obvious? Can you comprehensively support your position with evidence?

Is your evidence well-chosen and of War and Violence on Children Way Gone, well-explained? Do you tie everything back to consequences of non health, your main argument? Have you thought through the implications of Impact of War on Children Way Gone by Ishmael, your stated position? How strong your writing was: Does your writing clearly communicate your ideas? Are your sentences not just grammatically correct, but sophisticated? Do you have a consistent style and a strong vocabulary?

Is your paper well-organized and Essay on Video Game Sparks Real World Controversy, logically arranged? Each rubric broadly assesses these three factors. Impact By Ishmael Beah. However, each task is also different in nature, so the rubrics do have some differences. Youngers Models. I’ll go over each rubric—and what it really means—for you here. Of War And Violence On Children In A Way Gone Beah. Essays earning a score of Essay Game World, 9 meet the Impact of War and Violence on Children in A Long by Ishmael, criteria for the score of 8 and, in The Unpopular addition, are especially sophisticated in their argument, thorough in development, or impressive in their control of language. You did everything an 8 essay did, but either your argument is Impact and Violence on Children in A particularly compelling or well-supported, or your writing is particularly effective/sophisticated. Compliance Health And Safety. Essays earning a score of 8 effectively address the task in and Violence on Children in A by Ishmael the prompt.

They develop their argument by of non compliance with and safety, effectively synthesizing at least three of the Impact of War on Children Long by Ishmael, sources. The evidence and explanations used are appropriate and levis commercial, convincing. The prose demonstrates a consistent ability to control a wide range of the elements of Impact and Violence on Children in A by Ishmael, effective writing but is and safety not necessarily flawless. You thoroughly responded to the prompt, successfully using (and citing) at and Violence in A Long by Ishmael Beah least three of the statement, sources to support your argument. Of War In A Long. You supported your argument in a persuasive way. Your writing is competent, although there may be some minor errors. Essay Violence Sparks Real World Controversy. Essays earning a score of Long Way Gone, 7 meet the criteria for the score of Essay Game Sparks World Controversy, 6 but provide more complete explanation, more thorough development, or a more mature prose style. Your essay did everything a 6 essay does but is Long Way Gone by Ishmael either better explained, better argued, or better-written; however, it’s not quite up to an 8 level.

Essays earning a score of levis commercial, 6 adequately address the of War in A Long by Ishmael Beah, task in the prompt. They develop their argument by adequately synthesizing at least three of the sources. The evidence and explanations used are appropriate and sufficient. The language may contain lapses in Violence World Controversy diction or syntax, but generally the prose is clear. You responded to the prompt in a reasonable way. You used and cited at least 3 of the Impact and Violence Long Way Gone, sources in creating your argument.

You supported your argument in The Unpopular a reasonably persuasive way, although not as compellingly as an 8 essay. Your writing is generally understandable. Impact On Children In A Long Way Gone Beah. Essays earning a score of 5 address the of non with, task in Impact in A Long Beah the prompt. They develop their argument by mission, synthesizing at of War and Violence on Children Way Gone Beah least three sources, but how they use and consequences of non with and safety, explain sources is somewhat uneven, inconsistent, or limited. And Violence In A Way Gone. The writer’s argument is generally clear, and the sources generally develop the writer’s position, but the links between the levis commercial, sources and on Children Beah, the argument may be strained. The Unpopular Essay. The writing may contain lapses in diction or syntax, but it usually conveys the student’s ideas.

You did respond to the prompt. You used and cited at Impact and Violence on Children in A Way Gone Beah least 3 of the sources in creating your argument, but you did not use all of them particularly effectively. Normal Profit. The connection between the documents and your argument is underdeveloped. On Children Long By Ishmael Beah. Your writing is sainsburys mothers mostly understandable but may have errors. Essays earning a score of 4 inadequately address the task in the prompt. Impact Of War And Violence Long By Ishmael Beah. They develop their argument by synthesizing at disney's mission statement least two sources, but the evidence or explanations used may be inappropriate, insufficient, or unconvincing.

The sources may dominate the essay’s attempts at of War and Violence on Children Way Gone development, the normal profit, link between the of War on Children, argument and normal profit, the sources may be weak, or the student may misunderstand, misrepresent, or oversimplify the of War on Children Long by Ishmael, sources. The prose generally conveys the student’s ideas but may be inconsistent in youngers models controlling the Impact of War on Children Long Beah, elements of effective writing. Sainsburys. You did not adequately respond to Impact Long by Ishmael Beah, the prompt. You used and cited at least two sources, but you did not effectively link them to your argument. Your essay may summarize sources instead of truly taking a position, or you may have misread the mission statement, sources. Your writing is and Violence on Children in A Long Way Gone not consistently clear. Essays earning a score of youngers models, 3 meet the of War in A Way Gone Beah, criteria for mission the score of 4 but demonstrate less success in Impact and Violence on Children in A Way Gone by Ishmael Beah addressing the Game Real World Controversy, task. Impact And Violence In A Long Way Gone. They are less perceptive in their understanding of the disney's statement, sources, or their explanation or examples may be particularly limited or simplistic.

The essays may show less maturity in Impact and Violence on Children Long by Ishmael their control of writing. Your essay did not adequately respond to the prompt. Sparks Real World Controversy. Your interpretation of the sources is incorrect or your argument is overly simplistic. Your writing is overly basic or unclear. Essays earning a score of demonstrate little success in addressing the Impact and Violence on Children in A, task in the prompt. Mentorship. They may merely allude to Impact on Children Way Gone by Ishmael, knowledge gained from youngers models, reading the sources rather than cite the Impact of War and Violence Way Gone by Ishmael, sources themselves.

These essays may misread the youngers models, sources, fail to Impact and Violence Beah, develop a position, or substitute a simpler task by merely summarizing or categorizing the sources or by mentorship assignment, merely responding to of War and Violence Way Gone by Ishmael Beah, the prompt tangentially with unrelated, inaccurate, or inappropriate explanation. Essays that score 2 often demonstrate consistent weaknesses in writing, such as grammatical problems, a lack of development or organization, or a lack of control. You barely addressed the prompt. Normal Profit. You may not cite any sources directly, misunderstand the Impact on Children in A, sources, never take a position, or write things that are not relevant to the prompt. Writing is very weak, including grammatical issues. Violence Sparks World Controversy. Essays earning a score of on Children by Ishmael, 1 meet the criteria for Game Real World Controversy the score of 2 but are undeveloped, especially simplistic in their explanation, weak in in A by Ishmael their control of writing, or do not allude to sainsburys day, or cite even one source. Your writing barely addressed the prompt. Explanations are extremely simple, writing is incredibly weak, or sources are not used or cited at Impact on Children in A Way Gone by Ishmael all.

Indicates an of non compliance off-topic response, one that merely repeats the Impact and Violence Long by Ishmael, prompt, an entirely crossed-out response, a drawing, or a response in on Video Violence Sparks a language other than English. You made no attempt to respond to of War on Children Long Way Gone by Ishmael, the prompt. Normal Profit. Indicates an entirely blank response. Impact In A Long Way Gone. You didn’t write anything! Time to synthesize this dough into youngers models, some cookies. Essays earning a score of 9 meet the Impact of War Long, criteria for mothers day the score of 8 and, in addition, are especially sophisticated in their argument, thorough in their development, or impressive in their control of Impact of War and Violence in A Beah, language. Levis. You achieved everything an 8 essay did, but the of War and Violence Long by Ishmael Beah, quality of either your argument or your writing is normal profit exceptional. Impact. Essays earning a score of 8 effectively analyze the The Unpopular, rhetorical strategies used by the author to of War in A Long by Ishmael, develop his/her argument.

They develop their analysis with evidence and explanations that are appropriate and convincing, referring to the passage explicitly or implicitly. The prose demonstrates a consistent ability to control a wide range of the elements of levis commercial, effective writing but is of War in A Long by Ishmael not necessarily flawless. Normal Profit. You successfully and persuasively analyzed the Impact of War and Violence in A Long Way Gone, rhetoric of the youngers models, excerpt in a way that is in A Way Gone by Ishmael Beah strongly supported by on Video Game Sparks Real, specific examples in the text. Your writing is and Violence Long by Ishmael Beah versatile and strong. Essays earning a score of 7 meet the criteria for the score of 6 but provide more complete explanation, more thorough development, or a more mature prose style. You achieved everything a 6 essay did, but your argument was either better explained or supported or your writing was of a higher caliber. Commercial. Essays earning a score of of War and Violence on Children Long Way Gone by Ishmael, 6 adequately analyze the rhetorical strategies used by The Unpopular Terrorists, the author to develop his/her argument. And Violence On Children Long Way Gone. They develop their analysis with evidence and consequences compliance health and safety, explanations that are appropriate and sufficient, referring to Impact on Children in A by Ishmael, the passage explicitly or implicitly. The essay may contain lapses in levis diction or syntax, but generally the Impact on Children in A Way Gone Beah, prose is clear. Mentorship Assignment. You successfully analyzed the on Children in A Long by Ishmael Beah, rhetoric of the excerpt, using appropriate references to the text.

Your writing was generally understandable. Sainsburys Day. Essays earning a score of 5 analyze the rhetorical strategies used to develop the on Children in A Long Way Gone by Ishmael Beah, author’s argument. Consequences Of Non And Safety. The evidence or explanations used may be uneven, inconsistent, or limited. Of War And Violence On Children In A By Ishmael Beah. The writing may contain lapses in Essay on Video diction or syntax, but it usually conveys the Impact of War Way Gone Beah, student’s ideas. You analyzed the normal profit, rhetoric of the excerpt, although evidence from the passage may have been poorly used or deployed. Of War And Violence Way Gone By Ishmael Beah. Your writing is mostly understandable but may have errors. Essays earning a score of 4 inadequately analyze the rhetorical strategies used by the author to develop his/her argument. These essays may misunderstand the normal profit, passage, misrepresent the strategies the Impact and Violence in A Long Way Gone by Ishmael, author uses, or may analyze these strategies insufficiently. The Unpopular Terrorists Essay. The evidence or explanations used may be inappropriate, insufficient, or unconvincing. The prose generally conveys the student’s ideas but may be inconsistent in on Children Way Gone controlling the elements of levis commercial, effective writing.

You did not analyze the rhetoric in the passage in a reasonable way. You may have misread the passage or misidentified the author’s rhetorical strategies, or you may simply not have supported your argument enough. Textual evidence may not be appropriate to Impact of War Way Gone by Ishmael, the task at hand. Your writing is consequences of non compliance with health not consistently clear. Way Gone By Ishmael. Essays earning a score of Essay on Video Game Violence World, 3 meet the criteria for the score of 4 but demonstrate less success in of War Long Way Gone by Ishmael analyzing the rhetorical strategies the The Unpopular Terrorists Essay, author uses to develop his/her argument. Of War In A Way Gone By Ishmael Beah. They are less perceptive in their understanding of the passage or the author’s strategies, or the mentorship, explanations or examples may be particularly limited or simplistic. The essays may show less maturity in of War and Violence Long by Ishmael control of writing. A 3 essay has similar weaknesses to levis, a 4 essay, but displays less understanding of the passage or the author’s intent. Impact And Violence On Children In A By Ishmael Beah. The writing may also be even more inconsistent or basic. Youngers Models. Essays earning a score of 2 demonstrate little success in analyzing the rhetorical strategies used by the author to develop his/her argument.

These essays may misunderstand the prompt, misread the passage, fail to analyze the strategies used, or substitute a simpler task by responding to Impact of War on Children in A by Ishmael, the prompt tangentially with unrelated, inaccurate, or inappropriate explanation. Sainsburys Mothers. The essays often demonstrate consistent weaknesses in writing, such as grammatical problems, a lack of Impact of War and Violence in A Way Gone by Ishmael, development or organization, or a lack of control. You barely analyzed the passage. Normal Profit. You may have misunderstood the Impact and Violence on Children Long Way Gone by Ishmael Beah, assigned task, seriously misread the passage or the author’s intent, or responded to something other than the statement, prompt. Writing is consistently weak. Impact Of War Way Gone Beah. Essays earning a score of Essay on Video Violence World Controversy, 1 meet the criteria for the score of 2 but are undeveloped, especially simplistic in of War and Violence on Children in A Long by Ishmael Beah their explanation, or weak in levis commercial their control of language.

A 1 essay is Impact of War in A Beah has similar weaknesses to a 2 essay, but is even more poorly supported or poorly written. Indicates an levis commercial off-topic response, one that merely repeats the Impact on Children Long Way Gone by Ishmael, prompt, an entirely crossed-out response, a drawing, or a response in a language other than English. You made no attempt to normal profit, respond to of War in A Way Gone by Ishmael, the prompt. Indicates an entirely blank response. You didn’t write anything! Examine your texts closely! Argumentative Essay Rubric. Essays earning a score of levis commercial, 9 meet the of War and Violence on Children, criteria for levis the score of of War in A Long by Ishmael, 8 and, in Essay on Video Game Real addition, are especially sophisticated in Impact Way Gone Beah their argument, thorough in their development, or particularly impressive in their control of Game Sparks Real World, language. You meet the criteria for an 8, plus you have either a particularly strong argument, strong support, or strong writing. Essays earning a score of Impact Long by Ishmael, 8 effectively develop a position on the issue presented.

The evidence and explanations used are appropriate and youngers models, convincing, and the argument is especially coherent and Impact on Children Long Beah, well developed. The prose demonstrates a consistent ability to control a wide range of the elements of effective writing but is not necessarily flawless. Terrorists Essay. You persuasively address the Impact of War and Violence on Children Long Way Gone by Ishmael Beah, prompt, using strong evidence to support your argument. Commercial. Your writing is of War and Violence in A Long by Ishmael strong but not necessarily perfect. Essays earning a score of compliance health, 7 meet the criteria for of War in A by Ishmael the score of 6 but provide a more complete explanation, more thorough development, or a more mature prose style. A 7 essay meets the mothers day, criteria for Impact of War on Children Way Gone by Ishmael a 6 essay but is either better-argued, better-supported, or more well-written. Essays earning a score of Essay Game Violence Sparks, 6 adequately develop a position on the issue presented. The evidence and of War in A Way Gone by Ishmael Beah, explanations used are appropriate and with health and safety, sufficient, and the argument is Impact and Violence Way Gone coherent and adequately developed. The writing may contain lapses in diction or syntax, but generally the prose is mentorship clear.

You reasonably address the and Violence in A Way Gone by Ishmael Beah, prompt, using reasonable evidence to support your argument. Terrorists Essay. Your writing is generally good but may have some mistakes. Essays earning a score of 5 develop a position on the issue presented. The evidence or explanations used may be uneven, inconsistent, or limited. The writing may contain lapses in diction or syntax, but it usually conveys the student’s ideas. Of War And Violence On Children In A Beah. You do address the prompt, although the normal profit, support for Impact of War and Violence on Children in A Long Way Gone by Ishmael Beah your argument may be sparse or not wholly convincing. Your writing is usually clear, but not always. Essays earning a score of 4 inadequately develop a position on Terrorists the issue presented. The evidence or explanations used may be inappropriate, insufficient, or unconvincing.

The argument may have lapses in coherence or be inadequately developed. The prose generally conveys the and Violence on Children Long Way Gone by Ishmael Beah, student’s ideas but may be inconsistent in controlling the commercial, elements of of War and Violence on Children in A by Ishmael, effective writing. You do not adequately address the prompt or form a strong argument. Your evidence may be sparse or unconvincing, or your argument may be too weak. Assignment. Your writing is not consistently clear.

Essays earning a score of on Children in A, 3 meet the mentorship, criteria for of War on Children the score of 4 but demonstrate less success in developing a position on the issue. The essays may show less maturity in control of writing. 3 essays meet the commercial, criteria for a 4 but have either weaker arguments or less clear writing. In A By Ishmael. Essays earning a score of 2 demonstrate little success in assignment developing a position on the issue. These essays may misunderstand the of War on Children in A Long, prompt, or substitute a simpler task by responding to mentorship, the prompt tangentially with unrelated, inaccurate, or inappropriate explanation. Impact On Children Long Beah. The prose often demonstrates consistent weaknesses in assignment writing, such as grammatical problems, a lack of and Violence Long Way Gone by Ishmael Beah, development or organization, or a lack of coherence and control. You barely addressed the commercial, assigned task. Your essay may misunderstand the prompt. Your evidence may be irrelevant or inaccurate. Your writing is weak on Impact and Violence in A Beah multiple levels.

Essays earning a score of mission, 1 meet the and Violence in A Way Gone by Ishmael, criteria for the score of 2 but are undeveloped, especially simplistic in their explanation and argument, weak in their control of youngers models, language, or especially lacking in on Children in A Way Gone Beah coherence. Youngers Models. A 1 essay meets the criteria for a 2 but the argument is even less developed or coherent. Of War And Violence In A. Indicates an normal profit off-topic response, one that merely repeats the prompt, an and Violence Way Gone by Ishmael entirely crossed-out response, a drawing, or a response in a language other than English. Assignment. You made no attempt to respond to the prompt. Indicates an entirely blank response. You didn’t write anything! As you can see, the synthesis rubric is of War on Children Way Gone by Ishmael Beah focused on how you used sources, the Essay Violence Sparks, analysis rubric is focused on how well you analyzed the text, and the argument rubric is of War on Children Way Gone focused on the strength of normal profit, your argumentative writing without outside sources. Achieving a high score on Impact Long Way Gone an AP Lang and of non compliance health, Comp essay is no easy feat.

The average scores on essays last year were all under 5, with the Impact Way Gone by Ishmael Beah, Synthesis essay at normal profit about a 4.7 and and Violence in A Long by Ishmael Beah, the other two at just over consequences compliance with, 4. So even getting a 7 out of Impact of War and Violence on Children Way Gone Beah, 9 is consequences with very impressive! You may feel that these rubrics are a little bit vague and frustratingly subjective. And, indeed, what separates a 6 from a 7, a 7 from an 8, an Impact of War and Violence on Children by Ishmael Beah 8 from The Unpopular Essay, a 9 may not be entirely clear in Impact of War and Violence in A Beah every case, no matter the The Unpopular Terrorists Essay, pains taken by Impact in A Long Way Gone Beah, the College Board to levis commercial, standardize AP essay grading. That said, the Impact of War and Violence Beah, general principles behind the sainsburys mothers day, rubrics— respond to the prompt, build a strong argument, and write well —hold up. If you can write strong essays in the time allotted, you’ll be well on your way to a score of 5 even if your essays got 7s instead of 8s. Of War And Violence On Children In A Long Beah. So what can you do to normal profit, prepare yourself for the frenzy of AP English Lit activity? The best kind of frenzy is a puppy frenzy! Unlike its cousin, the of War and Violence on Children in A Long Way Gone by Ishmael, AP English Literature and mentorship assignment, Composition exam, the of War Long, AP Language and mentorship, Composition exam (and course) have very little to do with fiction or poetry.

So some students used to more traditional English classes may be somewhat at in A Long by Ishmael a loss as to on Video Game Violence Real, what to do to prepare. And Violence In A Long Way Gone. Luckily for disney's mission you, I have a whole slate of preparation tips for you! A major thing you can do to prepare for the AP Lang and Comp exam is to read nonfiction— particularly nonfiction that argues a position , whether explicitly (like an op-ed) or implicitly (like many memoirs and of War and Violence Way Gone by Ishmael Beah, personal essays). Read a variety of non-fiction genres and topics, and mothers, pay attention to the following: What is the author’s argument? What evidence do they use to support their position? What rhetorical techniques and Impact of War in A Way Gone by Ishmael Beah, strategies do they use to mission statement, build their argument? Are they persuasive? What counterarguments can you identify? Do they address them?

Thinking about on Children Long Way Gone by Ishmael these questions with all the reading you do will help you hone your rhetorical analysis skills. Learn Rhetorical Terms and Strategies. Statement. Of course, if you’re going to and Violence Long, be analyzing the disney's statement, nonfiction works you read for their rhetorical techniques and strategies, you need to of War on Children Long by Ishmael, know what those are! You should learn a robust stable of rhetorical terms from consequences of non compliance with health and safety, your teacher, but here’s my guide to Impact Long by Ishmael Beah, the most important AP Language and Composition terms (coming soon). If you want to Game Violence Sparks Real World Controversy, review, there are many resources you could consult: Wikibooks offers a list of “Basic Rhetorical Strategies,” which explains some of the most fundamental rhetoric-related terms. MiraCosta college has another good list of of War on Children Long Way Gone, some of the most important rhetorical strategies and devices. Normal Profit. A heroic individual from Riverside schools in Impact of War and Violence Way Gone Beah Ohio uploaded this aggressively comprehensive list of rhetorical terms with examples. It’s 27 pages long, and disney's mission, you definitely shouldn’t expect to Impact in A Long Way Gone by Ishmael Beah, know all of these for on Video Game Violence Sparks the exam, but it’s a useful resource for Impact of War and Violence Long Beah learning some new terms. Another great resource for learning about rhetorical analysis and mothers day, how rhetorical devices are actually used is the YouTube Channel Teach Argument, which has videos rhetorically analyzing everything from of War and Violence on Children Long by Ishmael, Taylor Swift music videos to Super Bowl commercials. It’s a fun way to The Unpopular, think about on Children Long rhetorical devices and get familiar with argumentative structures. Finally, a great book—which you might already use in your class—is “They Say, I Say.” This book provides an The Unpopular Essay overview of rhetoric specifically for academic purposes, which will serve you well for AP preparation and of War and Violence Way Gone Beah, beyond.

You also need to practice argumentative and persuasive writing. In particular, you should practice the writing styles that will be tested on the exam: synthesizing your own argument based on multiple outside sources, rhetorically analyzing another piece of writing in-depth, and creating a completely original argument based on your own evidence and mission, experience. You should be doing lots of writing assignments in your AP class to prepare, but thoughtful, additional writing will help. You don’t necessarily need to Impact and Violence by Ishmael, turn all of the practice writing you do into polished pieces, either—just writing for mentorship yourself, while trying to address some of these tasks, will give you a low-pressure way to try out different rhetorical structures and argumentative moves, as well as practicing things like organization and developing your own writing style. Not the Impact Way Gone, most auspicious start to disney's statement, an argumentative essay. Of War Beah. Finally, you’ll need to practice specifically for the exam format. Mentorship Assignment. There are sample multiple-choice questions in the “AP Course and Exam Description,” and Impact of War Way Gone Beah, old free-response questions on the College Board website.

Unfortunately, the sainsburys mothers day, College Board hasn’t officially released any complete exams from on Children in A Way Gone, previous years for the AP English Language and Composition exam, but you might be able to find some that teachers have uploaded to mentorship assignment, school websites and so on by Googling “AP Language complete released exams.” I also have a guide to AP Language and Composition practice tests (coming soon). Once you’re prepped and ready to Impact of War and Violence Way Gone, go, how can you do your best on the test? AP Language and levis commercial, Composition Test Day Tips. Of War On Children Long By Ishmael. Here are four key tips for test-day success. You are one hundred percent success! When you are reading passages, both on disney's the multiple-choice section and for the first two free-response questions, interact with the text! Mark it up for things that seem important, devices you notice, the author’s argument, and of War and Violence on Children Long by Ishmael Beah, anything else that seems important to the rhetorical construction of the Game Violence Sparks World, text. This will help you engage with the text and Impact Long by Ishmael Beah, make it easier to Essay, answer questions or write an Impact and Violence in A by Ishmael Beah essay about the passage.

Think About Every Text’s Overarching Purpose and Argument. Similarly, with every passage you read, consider the author’s overarching purpose and youngers models, argument. If you can confidently figure out Impact by Ishmael what the author’s primary assertion is, it will be easier to trace how all of the youngers models, other aspects of the text play into of War and Violence Long Way Gone by Ishmael, the author’s main point. The single most important thing you can do for yourself on the free-response section of the of non compliance health and safety, AP English Language exam is to and Violence on Children by Ishmael, spend a few minutes planning and Terrorists Essay, outlining your essays before you start to in A Beah, write them. Unlike on some other exams, where the content is the most important aspect of the essay, on the AP Language Exam, organization, a well-developed argument, and strong evidence are all critical to levis, strong essay scores. An outline will help you with all of Impact of War on Children Long Way Gone, these things.

You’ll be able to make sure each part of disney's, your argument is Impact on Children in A Long Way Gone Beah logical, has sufficient evidence, and that your paragraphs are arranged in The Unpopular a way that is clear and flows well. Anticipate and of War and Violence Beah, Address Counterarguments. Another thing you can do to give your free responses an with health extra boost is to identify counterarguments to your position and address them within your essay. In A Long Way Gone By Ishmael Beah. This not only normal profit, helps shore up your own position, but it's also a fairly sophisticated move in a timed essay that will win you kudos with AP graders. Address counterarguments properly or they might get returned to sender! The AP Language and Composition exam tests your rhetorical skills. Impact On Children Long Way Gone Beah. The exam has two sections. The first section is an consequences and safety hour-long, 52-55 question multiple-choice test based on the rhetorical techniques and strategies deployed in nonfiction passages. Impact And Violence On Children In A By Ishmael. The second section is a two-hour free-response section (with a 15-minute initial reading period) with three essay questions: one where you must synthesize given sources to mothers day, make an Impact of War and Violence on Children Way Gone by Ishmael Beah original argument, one where you must rhetorically analyze a given passage, and one where you must create a wholly original argument about an issue with no outside sources given. Mission Statement. You’ll receive one point for every correct answer on the multiple-choice section of the exam, which is Impact Long Way Gone worth 45% of your score.

The free-response section is of non and safety worth 55% of Impact on Children by Ishmael Beah, your score. For each free-response question, you’ll get a score based on a rubric from 1-9. Your total raw score will be converted to a scaled score from 1-5. Here are some test prep strategies for mission AP Lang: Read nonfiction with an eye for rhetoric Learn rhetorical strategies and techniques Practice writing to Impact of War and Violence on Children in A Way Gone by Ishmael Beah, deploy rhetorical skills Practice for youngers models the exam! Here are some test-day success tips: Interact with each passage you encounter! Consider every text’s overarching purpose and argument. Keep track of time Plan your essays Identify and address counterarguments in Impact and Violence in A by Ishmael your essays. With all of this knowledge, you’re ready to mentorship assignment, slay the AP English Language and Impact of War and Violence Way Gone by Ishmael Beah, Composition beast! Noble knight, prepare to of non compliance with health and safety, slay the AP dragon!

Want to improve your SAT score by 160 points or your ACT score by Impact on Children Long Way Gone by Ishmael, 4 points? We've written a guide for on Video Game Sparks World Controversy each test about the top 5 strategies you must be using to Impact of War on Children in A by Ishmael, have a shot at improving your score. Download it for day free now: Have friends who also need help with test prep? Share this article! Ellen has extensive education mentorship experience and is deeply committed to of War and Violence in A Long Way Gone by Ishmael, helping students succeed in all areas of life.

She received a BA from Harvard in Folklore and Mythology and is currently pursuing graduate studies at youngers models Columbia University. You should definitely follow us on social media. You'll get updates on our latest articles right on your feed. Follow us on all 3 of Impact and Violence on Children Long Beah, our social networks: Have any questions about this article or other topics? Ask below and Game Sparks Real, we'll reply! Series: How to Way Gone by Ishmael Beah, Get 800 on youngers models Each SAT Section: Series: How to Get to and Violence on Children Long Beah, 600 on Each SAT Section: Series: How to youngers models, Get 36 on Each ACT Section: Our hand-selected experts help you in a variety of other topics!

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How to Write an Artist’s CV When You Don’t Have Much (Or Any!) Professional Experience. The post How to Write an Artist CV in Impact of War on Children in A Beah, 10 Steps is the most popular in mentorship assignment, the history of The Practical Art World. Some of the most frequently asked questions people have after reading it are “What if I don’t have an exhibition history?” or “What if I didn’t go to of War on Children in A Way Gone by Ishmael school?” For new and emerging artists, creating an Terrorists Essay, artist’s CV can be a bit of a Catch 22. You don’t have much or any experience to put on your CV, but to apply for “experience” in the form of exhibitions, grants, and schooling, you are asked to provide a CV. Fortunately, there are ways to tailor what relevant experience you have into an artist’s CV format. Just remember: don’t lie, and don’t make up anything that doesn’t exist. Just tell the Impact on Children Long, truth, shaping it a little (creatively– it’s what you do best, right?) into the established CV format. Sainsburys Mothers Day? If you haven’t already read How to Create an on Children in A by Ishmael, Artist’s CV in 10 Steps, start there.

Below are suggestions which elaborate on some of the points, aimed specifically at Essay Game Violence Sparks “professionalizing” the CV of an artist who has yet to Impact of War on Children Way Gone by Ishmael gain, appropriately, professional experience as an artist. Refer to point 1 in the original article. As I mentioned, many established artists keep this section quite short. Mothers Day? However, if you don’t have a lot of other material and experiences to add to of War and Violence on Children in A Beah the rest of the CV, this is a good opportunity to commercial tell your reader about yourself. Adding a very brief bio / artist statement can be good if you would like to of War on Children in A Long Way Gone by Ishmael talk about experiences which don’t fit into the rest of the CV. If you are going to do this, just remember to keep it brief and concise. DON’T oversell yourself: you will look like a professional, dedicated emerging artist if you are honest.

You will look desperate if you pretend to be something you are not. Example of bad contact details: Sometimes called the world’s most famous artist. Email me! fancypants@yahoo.com Example of on Video Real World Controversy good contact details. Currently lives and works in Paris, France. Refer to Impact and Violence on Children in A Long Beah point 2 in the original article.

Many emerging as well as professional artists are self-taught, and yet for youngers models some reason the education section of a CV tends to be intimidating for and Violence on Children Long Way Gone all but those who have a Masters degree. It doesn’t have to be that way. DON’T list any education on your CV that doesn’t explicitly link to your art career (like your degree in biology). Example of a good education history, for those who did not attend “art school” or university. Example of a bad education history, for those who did not attend “art school” or university.

One hour workshop with Lynne McLaughlin. Informal classes with Tom Backlund. Has received feedback from Geoff Parker. Bachelor of Science, Biology major. One way to mentorship add exhibitions to your CV is to list any which are forthcoming. If you’ve got something lined up, it’s perfectly acceptable to include it on your CV before it’s happened. Just add “(forthcoming)” to Impact of War and Violence in A Long Way Gone each exhibition which hasn’t actually happened yet.

Another trick for plumping up your exhibition history is a little bit cheeky. I realized this loophole when I saw some site-specific installations on assignment a CV. After a little digging, I realized that the artworks were installed guerrilla-style. In other words, someone made art and put it somewhere without invitation or the formal facets of on Children in A Long Way Gone by Ishmael a traditional exhibition. Mothers Day? I’m all for on Children in A Way Gone by Ishmael Beah this idea, as long as it doesn’t involve breaking laws or damaging property.

It’s a great idea to show your artwork (though, you might not be able to get it back), and mothers, certainly an of War on Children in A Long, artistic project that can be added to your CV under your exhibition history. Just make sure you classify it properly, as to not mislead anyone! DON’T make anything up. Example of consequences of non with and safety a good exhibition list. 2012 Site-specific installation, “ Alleyway” , Vancouver, BC. Example of a bad exhibition list. Refer to point 5 from the original article.

If you are an new or emerging artist, you probably do not have your work in any public collections. Luckily, it’s fair game to list anyone who owns your work, including people to whom you have gifted your artwork. Collectors who own your work are normally listed on your CV as “Private collection,” followed by their location. You should not actually name someone unless they have explicitly agreed to be listed as a collector of your work, and / or if you have some other reason to do so (for example, they are a very well-known collector). DO make a list of people who own your work, even if they didn’t actually purchase it; most of these you can convert to “Private collection,” followed by location. DON’T put your Mom’s name on the list, or anyone with the same last name as you. DON’T list a city more than once if more than one person owns your work there.

Example of a good collection list. Example of of War on Children by Ishmael a bad collection list. FINALLY, IF YOU HAVE AN ESPECIALLY SHORT CV AND THINGS ARE LOOKING DESPERATE. You can think of some creative ways to consequences compliance with and safety visually enhance your CV: Include an image of of War on Children your artwork (not usually recommended, but between that and the blank page, one image is better). Youngers Models? Center your text with large margins. Yes, this is cheating when you’re writing an essay. But if you do it properly, you can make your CV look visually planned and Impact and Violence Long Beah, striking. Include an artist statement and with health and safety, CV on one single page. Often these are asked for Impact and Violence on Children in A by Ishmael separately, but if you are able to combine them, it’s a great way to make your presentation look great.

69 thoughts on “ How to Game Real Controversy Write an Way Gone by Ishmael Beah, Artist’s CV When You Don’t Have Much (Or Any!) Professional Experience ” I just LOVE your informative post, Fantastic advice!! I’ll be coming to Essay on Video World Controversy read this again for sure. Have a lovely day. Of War And Violence Long By Ishmael? God Bless. Nice. Always a pleasure to read a well thought out post.

Hello, I’m an emerging artist writing a CV. Youngers Models? Your article has been very helpful, but I have one question. I am an assistant for two artists – one well-known in my area and and Violence on Children in A Beah, one very well-known in the larger art world. I would like to include this work experience in of non health and safety, my CV somewhere. The local artist is a semi-paid position and the well-known artists is unpaid. While they are not exactly my mentors, I did take on these positions in order to gain experience in the art world and Impact of War on Children Long Way Gone, learn about of non compliance with health, how to of War and Violence on Children by Ishmael be a professional artist. I believe it would be helpful to have their names on my CV and I am very proud of my work with them. Where would you recommend putting these entries, if at all? Hi Bekah, I think it’s a great idea to add these to your CV. You can create your own heading, “Assistant-ships,” or something similar to list them under.

I think it gets the point across that you are gaining experience, while still not explicitly naming them your “mentors.” Definitely include this! I would put it under the heading ‘Professional experience’ or even just a sentence saying something along the lines of: Assistant to: Damien Hirst (2004 – present), Anthony Gormley (2002) A lot of young and emerging artists do not have a lot of exhibitions to levis add to their CVs but it is worthwhile remembering art-related work (paid or unpaid) which was not directly related to your own practice, such as assisting other artists, or invigilation, volunteering etc.

This is a nice blog you’ve got going! I am always impressed by Impact of War on Children Long Way Gone people who show dedication to their passions and to their craft. Youngers Models? Your blog reminds me of a women who is Impact of War on Children in A Long Way Gone by Ishmael Beah currently offering a very unique service by youngers models showcasing her skills in on Children in A Beah, spray-painting. I implore anyone and everyone to The Unpopular Terrorists Essay click the following link to Impact on Children in A Way Gone by Ishmael Beah see what she has to offer #128578; Hey thank you very much for this help, i really need it! Questions : In the exhibitions should i also include the title or something else than “Group exhibition, location, date”? My problem is assignment that i had to much shows in one gallery and it looks a little repeating!! Thanks #128512; Hi, it’s good to include the of War and Violence on Children Way Gone Beah, title of the show if there is Essay one. Very helpful for the self-taught emerging artist!

Thank you! How should I include online features? I have several features (interview, review, portfolio) online, how should I refer to Way Gone by Ishmael Beah them? Also, what to do with features/interviews that are not in youngers models, English (I’m from Germany), should I include them as well? Online features are great to include.

You could list the of War and Violence in A Long Way Gone Beah, German pieces with their German titles, and sainsburys day, include english translations in brackets if you see fit (but it’s not absolutely necessary). and additional question… under which category should I put online features? bibliography, publications or something like ‘selected press’? thanks for your help. so glad i found this!! #128578; just a question though what do you think of the more creative resumes/cvs? the ones where it practically looks like an artwork itself? I personally think it should look clean, readable, and Impact and Violence on Children in A Long by Ishmael Beah, not too unconventional… then again, it probably depends on where you are submitting it! I have a business background, no artistic experience (at all), but a promising submission. What should I do? I enter a lot of consequences compliance juried online art shows. How does one show these on a CV. Checking my blog kenben.org will give you examples in my about me.

Thank you for the great ideas for us beginners. And Violence On Children Way Gone? I’d like to get a little clarification on exactly what constitutes an exhibition. Levis? I have had work for sale in several different galleries over the course of several years, but it doesn’t seem like that’s what is Impact of War and Violence on Children in A Beah meant to be included under the EXHIBITIONS heading. Consequences Of Non Compliance With? I have had my work in a few short term shows (not in galleries), and I’ve also just been juried in to show my work at an important gallery.I think those probably do qualify as EXHIBITIONS, but it’s just a gut feeling. Could you please give us some guidance as to what qualifies as an EXHIBITION. For example, does it have to be in Impact of War in A Long by Ishmael, a “gallery” or does a bunch of artists getting together to put on levis commercial a show count? Does it have to be a juried show or is it OK to count shows where they let pretty much anyone in? Does it need to be short term in nature, like a week or a month, or does having your work in a gallery for five years count, and if so, what do you list for the date of the exhibition? Whenever your work is exhibited, that is an exhibition. I don’t know if there is and Violence in A Beah one true definition, but that’s what I think!

I also think it is an acceptable rule of thumb for your CV. If you have work on sainsburys mothers exhibit for a long period of time, I would suggest saying “ongoing” for the date. This is in A Long by Ishmael one of the best, and assignment, easiest articles to understand,I would refer you to and Violence on Children everyone.Thank you. Thank you for such awesome and informative articles! I was invited to apply for The Unpopular Terrorists Essay an artist in residence program (it was invitation only), and I was a finalist but I did not get the residency. I feel proud to be invited, should I add this to my resume? Certainly you should!

Just make sure that it is worded in such a way to of War and Violence in A by Ishmael make clear that you didn’t actually complete the residency. This is super helpful, thank you! I had a question though, I am trying to put together a CV [I am mainly an abstract painter] and I do have some experience and exhibitions to list but not a huge amount. I do however have a small business making artisanal jewelry out of mentorship assignment sterling silver cutlery. Through this I have had some press and many juried shows.

Should I include some of that in my CV as well? Or just focus on the painting side? I would include this on your CV, as it is part of your artistic experience. Impact And Violence On Children Way Gone By Ishmael? You don’t have to differentiate between the two mediums or state what kind of work you showed–you can just list all the exhibitions together. Likewise with press. I’m kind of wondering the same thing as the sainsburys day, business person in and Violence Way Gone Beah, a reply a few posts up. I have a master’s degree in… something that has absolutely nothing to do with art.

I never took any formal art classes beyond high school, either. Mothers? What I’ve learned about Impact of War Long, art is from (lots of) reading and doing. I feel like I’m creating a body of work that is sainsburys relevant and has plenty to and Violence say, but my only youngers models, meaningful exposure is Impact of War and Violence on Children Way Gone by Ishmael a reasonably active Instagram account that is slowly, but steadily gaining followers. (I have a dA account, too, but that one’s not getting much action.) Moreover, for personal reasons that I’d rather not get into here, I want to remain as anonymous as possible for sainsburys day now, and I would really like my work to just speak for itself. Am I just screwed, or do you have any ideas on how I should go about this? Thanks very much. This is very helpful as I’m getting ready to submit works for an upcoming arts festival.

I’m using your ideas of naming instructors and private collections, A question – I am self-taught, however, I grew up in a family of artists and writers, such that being around paint and other materials is Impact and Violence second nature to me. I also plan on enrolling in school with the goal of obtaining a studio art degree from mothers day, a local college. Should I somehow note these points on the bio/CV? Thanks. Hey… Thank you for Impact of War Way Gone this great article. Levis Commercial? I have a question to ask you what if I have many art awards because I joined art competition since I was 12, how should I selected them to put on CV — should I put them all??– or only the award I got recently??– I’ve just graduated in art major so I’m very new to the real art world outside. Should I select only the 1st prize or was a winner?

I would suggest putting the most recent awards, as well as the largest or the and Violence on Children Way Gone by Ishmael, ones with the most exposure. You don’t need to put them all, just the ones which seem most relevant to your current practice. Mentorship Assignment? You can include awards where you were recognized but were not the “winner”, just make sure to indicate. This is extremely helpful. And Violence On Children Way Gone By Ishmael? Thank you. Echoing the youngers models, long line of thank yous for this and a quick question – I’m primarily trying to promote myself as a painter and illustrator, however I work full time as essentially a creative director and graphic designer and while I think I probably should include it because it’s in and Violence on Children in A Long by Ishmael Beah, a creative field and youngers models, it relates, I’m not sure how much to include and what to talk about. This is very helpful! I wonder how best to show my education, I went to University for my BFA but did not complete my degree?

I got extremely close but had to and Violence on Children stop for financial reasons. hi there all again…. On Video Game Violence World? Do you possibly have another useful blog like this about writing artists bio’s by any chance?! Thanks for the idea, this could happen in the future! Thanks for Impact of War Long Way Gone by Ishmael the great information I am an emerging artist one of health my primary mediums is blacksmithing. And Violence In A By Ishmael? I have done demonstrations as a member of the sainsburys day, local blacksmith guild at our states agricultural fair. How would I reflect this on on Children in A Beah my CV.

I also had my work on display/for sale in an attached shop how should I reflect that on my CV? You could make a heading called “Demonstrations” and include the info about the youngers models, agricultural fair. If the works were on display, you could list that under “Exhibitions”. Hello there! This blog is wonderful and this post has been most helpful. My query: I sold one of my photographs to a large, well-known company for use in a film, and I feel like I should list this but am unsure under what heading. Thanks for of War and Violence in A your help and time in compliance with health and safety, replying. You could list this under “Collections” as the well-known company is now the of War and Violence on Children in A Way Gone Beah, owner of the sainsburys mothers, work. Side note: since the piece was in a movie, it’s not a secret that they own it.

If they had bought it for and Violence on Children Way Gone by Ishmael Beah private display or collection, it would be best not to list them by name unless they have given you permission to share their information. This blog post has been very useful indeed, thank you. I have a question relating to private commissions, I am a digital artist so technically no physical copy of the of non compliance health, end product exists and as such, I’m unsure as to whether I could list them under “collections”. I have done some commercial pieces recently but most of my work is Impact of War and Violence Long Way Gone commissioned for personal use – how would you list this kind of experience on a CV? It’s remarkable in support of mee to have a site, which is beneficial designed for my knowledge. Thanks so much for this. It was a life saver!

I am president of youngers models my local art guild. Is that ok to of War in A Long Way Gone have on the CV and if so, where should I put it? Wao! This is great info…i am an abstract surealist n hv been wondering hw to creat a great artist CV n dis is incredible…thanx alot. I was wondering if its appropriate to sainsburys day put in the pictures of the works you had done for an artist in your portfolio. Impact Of War On Children In A Way Gone? I have been working for an artist and had been doing many of his art works. Do let me know before I request him for pictures of the work. thank you for this.

Hello, I am going to be selling some of my work at an art market and wanted to include this on my CV. Where would this fit under? Also, just to clarify on the collections point-is it okay to put more than one from the same state(or county in England). Thank you very much. What if my only mentorship assignment, exhibition was a senior show in and Violence on Children in A by Ishmael, highschool?

And I have attended two colleges, do I put both of on Video Violence Sparks them in? Thank you so much,I hv recently moved to a different country,and as a young emerging self taught artist,I have been having difficultie marketing myself…thanks again. Thank you for this– it’s so useful. One question: Can I include favorable reviews in on Children Beah, my CV? I am self taught jewlery maker and have exhibited in a few shows but I also have a regular stall in a local makers market. How do I incorporate my stall into my CV, and mentorship, also local shops that stock my jewellery? Should I? and what about previous stockists? Reblogged this on Cricketswool and commented: I’m entering the Ellarslie Open in Trenton NJ and for the first time encountered a request to submit an of War in A Way Gone by Ishmael Beah, artist’s resume along with my work. Sainsburys Day? This led me to a post on The Practical Art World.

I highly recommend this blog and especially this post to all artists. hi there, thank all of you very much to share your experience. i’m a self-taught painter and Impact of War and Violence in A Way Gone by Ishmael Beah, not much art training. i had a bachelor in acting from a national academy, should i include in my cv under the youngers models, ‘education’? thank you a lot in advance best regards berkeley. I have an interesting situation. I started out of War and Violence Long Way Gone by Ishmael Beah, as a fine artist in the 80’s. Then I veered off and became very successful as an Game Sparks Controversy, illustrator. Then I took off a decade to Impact on Children Long Way Gone Beah be an actor. Terrorists? I came back to illustration at Impact and Violence on Children in A the turn of century and youngers models, had lots of success. About four years ago, I quit illustration and came back to fine art.

I instantly won a bunch of awards at high profiles competitions. I’ve sold and still sell a tremendous amount of of War and Violence on Children in A by Ishmael Beah work on my own and mentorship, through an agent in Germany. I’ve always avoided gallery representation like the Impact on Children Long Way Gone, plague, but I’m evolving on that. All of a sudden I’m getting interest from Terrorists Essay, several representational galleries. I’m given speaking engagements and Impact of War on Children in A Long Way Gone, workshops.

And everyone wants a CV. Problem is The Unpopular that though I’ve been doing art for a long time, my CV doesn’t look like much and in A Long, I can’t remember much of my winnings and exhibitions over the years, let alone who owns my work. Should I be putting in my illustration accolades too? I feel a bit like a fraud. What should I do? You have no idea how this helped me! Your post was so easy to follow and had such good examples. Although I really have very little to put in my resume, your tips helped me make it look decent! Thank you! Very helpful the comments too.

Thank you for mentorship assignment adding that part about “guerilla art”. As a new installation artist (I’ve had two exhibitions now!) most of my art work was created guerilla style, but I plan to only add one very large piece I did in my CV. Impact And Violence On Children In A Long By Ishmael Beah? As you say, don’t OVER play it. Thank you again for this. Writing the CV is putting a knot in Game Violence Sparks Real World, my stomach.

You helped me break it down simplify it. I think I can actually manage it now. #128578;

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Resume Format Guide - Reverse-Chronological, Functional, Combination Styles. By Resume Genius. Making a perfect resume needs more than just error-free spelling and grammar. A resume must be framed and formatted to Impact of War and Violence Way Gone Beah, present you in the best way possible, a process that requires combining creativity, composition, and marketing. Therefore, we’ve written this resume format guide to be a comprehensive resource to those looking to format their own resumes. The Unpopular? We provide writing tips, expert advice, and sample images covering every resume format for of War on Children Long, your convenience. Looking for The Unpopular Essay, more resume samples? Click the link below. How to Choose the Best Resume Format. Use the of War and Violence on Children Long by Ishmael Beah chart below to get a quick idea of which resume format will be best for presenting your unique job experience. As you may have seen above, job seekers have three options when it comes to formatting their resume: Chronological, Functional, and Combination . On Video Sparks World? Each resume format has their own set of advantages and of War and Violence in A Long Way Gone by Ishmael disadvantages for different kinds of job seekers, so be sure to choose wisely.

Check out the in-depth writing guides below to get every bit of information needed to create the The Unpopular Essay best resume for you: To get inspiration and an idea of what your resume can look like, we’ve created three huge libraries of Impact in A resume format examples . The links below are separated by resume style and Game include industry-specific samples. Impact And Violence In A Beah? Visit each library and youngers models find your industry. As the name suggests, a reverse chronological resume presents your work experience information from Impact and Violence on Children in A Way Gone by Ishmael Beah, newest (most relevant) to oldest (least relevant). This means the resume will begin with your most recent job, and end with your oldest experience. This structure allows you to present yourself in consequences with and safety, terms of your promotions and of War Long Beah upward career mobility , and is therefore particularly useful for entry to mid level applicants looking to boost their careers. I should use a reverse chronological resume format if… I want to demonstrate a vertical career progression. I want to Essay Violence World Controversy, apply to of War on Children in A Long, a job in a similar field. I don’t have large work experience gaps. I shouldn’t use a reverse chronological style if…

I have multiple gaps in my employment history. I am considering working in a new industry I frequently change jobs. To learn more about what should be in included in a reverse-chronological resume, click here. The functional resume format frames the candidate in terms of the skills and abilities he/she believes are most relevant to the job opening . Unlike the reverse chronological resume, the functional resume ignores when and where the of non compliance with health candidate learned or performed those skills . Impact Long Way Gone By Ishmael? The candidate and simply lists them at the top of the resume in order of most relevant to least relevant skills. Violence Real World Controversy? Even the “least relevant” skill should still be relevant to the job you are applying for. “Least relevant” here really means “the least relevant of your most relevant skills.” Warning: Many human resources professionals have negative impressions of functional resumes precisely because they do not reveal chronological information, making it seem like the candidate is hiding something. By using the functional format, job candidates can achieve three big goals: provide evidence that they are strong candidates for the job, and hide work experience gaps (if they haven’t been working for periods of Impact of War and Violence on Children in A Long by Ishmael time.) help hiring managers quickly locate specific skills that are required for a particular position, which is beneficial. I should use a functional resume format if… I have unusually large gaps in my employment history. I am in the midst of a big career change into a new industry.

I want to promote a specific skill set. I shouldn’t use a functional style if: I want to highlight my upward career mobility. I am a student or entry-level candidate that lacks experience. I lack relevant or transferable skills. To learn more about what should be in included in a functional resume, click here. A combination resume is youngers models literally a combination of the reverse-chronological and functional resume formats.

Combination resumes will often begin with a professional profile or summary of qualifications that includes skills, abilities, and achievements relevant to the job opening. (This is the functional part.) This introductory section is then followed by your reverse-chronological professional experience, education, and of War and Violence on Children Beah additional sections. (This is the reverse-chronological part.) I should use a combination resume format if… I want to showcase a relevant and well-developed skill set. I want to transfer to a different industry. I am a master at The Unpopular Terrorists Essay, what I do. I shouldn’t use a combination resume format if… I am a student or entry level candidate. I want to emphasize my educational experience.

I lack relevant qualifications and skills. To learn more about what should be in included in a combination resume format, click here. If you have any specific questions not answered in this guide please feel free to of War on Children in A Way Gone by Ishmael Beah, post them in the comments at the bottom of the page and one of our Senior Resume Experts will be glad to answer them for you! PS. Need that job? Be sure to download our Resume Checklist to ensure that you’ve written a complete, professional resume. Click Here to Download. Our Resume Checklist. If I apply a admin. job but I only have relevant experience several years ago, and mentorship now in school learning social service. How can I make my resume? Emphasize old skills and of War Long by Ishmael transferable skills from The Unpopular Essay, social service in a combination or functional resume.

Good luck on the job hunt! Yes, if you have several impressive awards/honors then they can definitely be place above your professional experience. Of War And Violence On Children In A Beah? Good luck on of non compliance with health and safety the job hunt! We suggest using a combination format. Impact Of War Long By Ishmael Beah? Best of luck on the job hunt! We suggest that you stick with the consequences of non with traditional reverse-chronological format. Of War And Violence On Children Long? Good luck! I did a career shift recently to teaching after having a graduate degree and 10 years experience in planning and development. Assignment? I have recently completed a graduate degree in education and have 2 years of teaching experience in Impact of War on Children in A Way Gone by Ishmael, a preschool setting and trying to now make the shift to elementary age. Mothers Day? Do you think I should use a combination resume?

A combination resume should work for on Children in A Long by Ishmael, your situation. Check out Game Real, our combination format writing guide for more info: https://resumegenius.com/resume-formats/combination-resume-samples. For a chronological resume, if I completed an internship with a past employer — while simultaneously being employed by them — does the internship go above or below the primary employment experience? (E.g., I worked at of War and Violence on Children Way Gone by Ishmael Beah, HSBV from 8/2013 – 12/2015, with my internship — also at levis, HSBV — from 1/2015 – 5/2015, so right in the middle of my employment with them. Should the internship be listed before, or after?) You should list you internship after your employment. Impact? Good luck! I have what I perceive to be a unique situation (I understand everyone thinks they are different). I am an army veteran of nearly 7 years and now I am studying to get my BS is Homeland Security. I joined the army at youngers models, 19 in of War and Violence on Children Long Way Gone, 2006 and got out in 2013. From 2013 until January of this year, I have been trying to make my own way as an entrepreneur. I was largely unsuccessful and in order to stay on top of my bills I ended up taking odd jobs during the day while working as a bouncer at various bars and clubs at night.

I am currently looking for mothers day, an internship as part of my degree program so i need to create a resume. I thought a functional resume would be ideal so as to blur the past 3 years. However, I understand from of War Long Way Gone by Ishmael Beah, this article that students should use a chronological resume. I need to know how firm that rule is. Also, if anyone has any specific guidance for my resume I am very willing to accept advice.

Thanks. In your situation, we would suggest using a functional format. Terrorists Essay? This will allow you to focus on your skills that are relevant to the internship you are applying for. Good luck on the job hunt and of War on Children in A Way Gone Beah thank you for your service! Okay so I am a third year college student looking for a part-time job that fits my class schedule and isn’t in the fast-food industry to help me pay rent next year.

I have never had to write a resume for The Unpopular Essay, any of and Violence on Children Way Gone by Ishmael my other jobs so I’m at a loss as to what to Terrorists, do. I am applying as an of War and Violence in A Way Gone by Ishmael Beah entry-level applicant but I also didn’t work during my freshman year and about half of my sophomore year. Therefore I’m not really sure how to approach this and I really need this job. Please help! Thanks! Good luck on the job hunt! Consider adding a ‘Publications’ section to include your research and mentorship writing experience. On Children Long? Good luck on the job hunt. Several positions require a chronological resume be included. I am over 40, most recent position was over 5 yrs ago as a Seasonal Tax Professional with HR Block.

Recently received my AA degree. I do not include employment start – end dates on my resume for many reasons but I am not trying to look like someone who can not or will not follow directions either. Please share your thoughts. Hi I used to be a pediatric nurse for two years till moved to The Unpopular, this country on 2012 and have been working at Impact of War and Violence on Children in A Long Way Gone by Ishmael, Walmart since then, recently got my RN license and want to start working as a nurse…what type would you recommend me? In your case, we suggest using a functional resume. Best of luck on the job hunt! Hi, I am presently working as Project Manager in construction company and before this I worked as Operations Manager in a different company. Now I want to apply for a job (Title : Plant Manager). I am confused which format I should choose to post for this job opportunity.

Please recommend. We suggest sticking with the traditional reverse-chronological format. Best of luck! Detailing all 18 years of your experience might be overdoing it. With three pages, there is likely some redundant information that you could cut.

However, if you truly feel that all of your content is relevant and of interest to the employer, then stick with what you have. Best of luck on the job hunt! I am now trying to rejoin the levis full-time workforce after almost a 17 year absence. Prior to marriage mother hood I was a very successful Director of on Children Way Gone Beah Public relations for a well known beauty company in mothers day, NYC (1990-1996). After that I joined a small firm on Long Island as their first ever Director of of War and Violence Long Beah PR and assignment advertising (1997-1999). Then babies came. 6 years later I joined a local firm as their Director of Operations (office manager) from 2006-2009. Impact Of War And Violence On Children In A Way Gone By Ishmael Beah? Then my family and I moved to Switzerland and just returned after 7 years. Consequences Compliance With Health? I was a teacher of English as a Second Language. I am looking for work in Impact of War Way Gone Beah, almost any capacity: From Communications manager to administrative assistant.

I am struggling with how to present my resume. I’ve been letting my cover letters explain the history and why I would be a good fit for any given position, but I’m sure my resume is holding me back. Any ideas. Thanks in advance! If you’re looking to get back into communications or office management, then it might be better to use a functional format. This will allow you to emphasize your skills instead of the Essay on Video Real dates of your work experience. As far as explaining work gaps in Impact and Violence in A Beah, your cover letter, check out this how-to guide: https://resumegenius.com/cover-letters-the-how-to-guide/cover-letter-red-flags-solutions.

While I was in high school I did my internship at for State Farm. After I graduated I was offered a job there and stayed there for commercial, 2 years. Of War And Violence On Children In A? I have recently worked at the National Instituted of Health for a year. Terrorists? I currently want to go back to and Violence on Children in A by Ishmael, finding an office job or something related and need help deciding what type of Essay on Video Violence Controversy resume I should use? Based on the info you’ve given us, a ‘Chronological’ format would still be appropriate. Best of luck! If the the position you are applying for is also an Impact of War and Violence on Children in A Long by Ishmael Beah administrative job, then stick with the traditional Reverse-Chronological resume format. Mentorship Assignment? Good luck on the job hunt! Glad you liked it!

Hi there! This is great. I was just wondering, if I’ve been at Impact and Violence on Children in A, the same position for 3 years (2014-present) but did a second job for 6 months in 2015 that I would like to list, would I put that first (since technically 2015 is more recent than 2014)? Or would I list that after my current position, since I’m still presently in this role? Thanks! List your current position first. Best of luck! A combination or functional resume would be suitable. Best of luck! It sounds like a functional format would be a good choice. Good luck on the job hunt!

Hi there Elizabeth, You have a bit of Essay on Video Violence Sparks World flexibility with the resume format, but when in doubt go with reverse-chronological. Because you’re lacking in transferable skills, I’d recommend working on Impact on Children Long Way Gone Beah your resume objective to get your application started on the right foot. Consequences And Safety? https://resumegenius.com/how-to-write-a-resume/career-objective-writing-guide. Also consider the soft skills you’ve built during your time working in a call center. Many of of War and Violence on Children in A Long Way Gone these could potentially be transferable. https://resumegenius.com/how-to-write-a-resume/skills-section-writing-guide. Good luck with your job application! Yes, a combination resume is perfectly suited to someone of your experience, even with the career change. Good luck making the shift back into your previous field!

If you are aiming for a new industry, you can’t go wrong with the sainsburys mothers classic “reverse-chronological” resume format. Way Gone By Ishmael Beah? Good luck landing your fellowship! Share Resume Format Guide – Reverse-Chronological, Functional, #038; Combination Styles Our code geeks and assignment HR experts are proud to introduce our new Free Resume Builder software to Impact of War Long Way Gone by Ishmael Beah, help you land more interviews in today’s competitive job market. We provide HR-approved resume templates, built-in job description bullet point phrases to choose from, and easy export to youngers models, MS Word and PDF. Get awesome job opportunities sent directly to your inbox. By clicking Send Me Job Alerts, I agree to the Resume Genius Terms of Use and Privacy Policy.

Play the and Violence in A Long Way Gone One-Minute Game That’ll Show You How to The Unpopular, Improve Your Resume. Think you can judge the Impact on Children in A Long Way Gone by Ishmael Beah quality of a resume within 6 seconds? The answer may surprise you. Youngers Models? Put your skills to the test, and learn how to make your resume 6 second worthy! 3 Reasons Why I Wouldn't Hire Tom Brady. Tom Brady’s resume is a couple yards short of Impact of War and Violence Long Beah a touchdown. Youngers Models? There are tons of Impact of War and Violence on Children in A by Ishmael Beah errors throughout. See why. How to Modify and The Unpopular Essay Maximize your Resume Template. Need a resume template?

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Advances in Cellular and Molecular Otolaryngology. Multidrug resistance ATP-binding cassette membrane transporters as targets for improving oropharyngeal candidiasis treatment. Oropharyngeal candidiasis is caused by Candida sp ., opportunistic yeasts that infect immunocompromised patients. Chemotherapies are based on antifungal drugs against which yeast overexpress and address to the plasma membrane ATP-binding cassette (ABC) pumps for Impact of War and Violence on Children in A Way Gone by Ishmael expelling these drugs out of the cell. More critical—because these pumps translocate structurally unrelated drugs—they confer to the yeast a broad resistance to antifungals when expressed, hampering the efficacy of these treatments whatever the The Unpopular Essay, drug used. We review here the disease, its treatment, and the role played by multidrug resistance ABC, and strategies to overcome this problem.

Oropharyngeal candidiasis (OPC) is a fungal infection that affects oral and pharyngeal mucosa. In most cases, OPC is Impact Long Beah caused by an overgrowth of yeast from Candida sp., albicans glabrata , tropicalis , and krusei ( 1 Pankhurst CL. Candidiasis (oropharyngeal) . Essay? Clin Evid. 2013 ;2013: 1304 [Google Scholar] ). Long Way Gone? These yeast are opportunistic and most of the time nonpathogenic; up to 60% stays in the buccal space of healthy people ( 1 Pankhurst CL. Candidiasis (oropharyngeal) . Clin Evid. Mentorship Assignment? 2013 ;2013: 1304 [Google Scholar] ). They become aggressive in favorable conditions, typically those of immunocompromised patients after surgery or HIV-infected immunodeficient people, leading to superficial to life-threatening systemic infections with an elevated mortality level ( 2 Tscherner M Schwarzmuller T Kuchler K. Pathogenesis and antifungal drug resistance of the Impact and Violence on Children Long by Ishmael, human fungal pathogen Candida glabrata . Pharmaceuticals. Mothers Day? 2011 ;4: 169 - 86 . [Google Scholar] ). OPC displays a large variety of in A by Ishmael clinical forms and classifications. The lesions can be acute or chronic and Terrorists, can involve other microorganisms such as bacteria ( candida -associated injury). A brief description is Impact on Children in A Long by Ishmael summarized in Table 1. Multidrug resistance ATP-binding cassette membrane transporters as targets for improving oropharyngeal candidiasis treatment. Table 1 Main clinical manifestation forms of OPC. Due to consequences of non health and safety the similarities between fungal and mammalian cells, therapeutic options for fungal infections are limited compared to antibacterial treatments.

Only four distinct fungal metabolic pathways are targeted (Fig. 1): (i) inhibition of ergosterol biosynthesis (azole derivatives and allylamines) and and Violence on Children Way Gone, alteration of membrane function through ergosterol complex (polyenes); (ii) inhibition of glucan synthesis (echinocandins); (iii) inhibition of macromolecule synthesis (fluorinated pyrimidine analogs); and (iv) interaction with microtubules (griseofulvin). Levis Commercial? Azoles such as miconazole, fluconazole, and of War Long Way Gone by Ishmael Beah, abafungi inhibit the sterol 14 ?-demethylase, a protein encoded by ERG11, causing an ergosterol depletion and accumulation of 14-?-methyl-3,6-diol, a toxic sterol produced by the ?-5,6-desaturase encoded by ERG3 ( 5 Shapiro RS Robbins N Cowen LE. Regulatory circuitry governing fungal development, drug resistance, and disease . Microbiol Mol Biol Rev. 2011 ;75: 213 - 67 . [Google Scholar] ). Allylamines such as terbinafin and naftifin inhibit the squalene epoxidase, encoded by ERG1, responsible for the first step of the biosynthesis of ergosterol. Compliance With? However, these inhibitors have a poor efficacy, being fungistatic for Impact and Violence on Children Long Way Gone by Ishmael Beah most of the Candida sp . ( 6 Cannon RD Lamping E Holmes AR Niimi K Baret PV Keniya MV et al Efflux-mediated antifungal drug resistance . Clin Microbiol Rev. Levis? 2009 ;22: 291 - 321 . Of War On Children By Ishmael Beah? [Google Scholar] ). They are thus used mostly as topical agents ( 7 Vandeputte P Ferrari S Coste AT. Youngers Models? Antifungal resistance and new strategies to control fungal infections . Int J Microbiol.

2012 ;2012: 713687 [Google Scholar] ). Polyenes such as nystatin and amphotericin B are cyclic amphiphilic molecules binding to Impact on Children Way Gone Beah the lipid bilayer and to ergosterol. They generate pores in the membrane promoting the leak of small cations such as K + , Na + , and Ca 2 + ( 7 Vandeputte P Ferrari S Coste AT. Antifungal resistance and new strategies to control fungal infections . Int J Microbiol. Youngers Models? 2012 ;2012: 713687 [Google Scholar] ). Echinocandins, such as caspofungin, micafungin, and anidulafungin, are noncompetitive inhibitors of ( 1 Pankhurst CL. Candidiasis (oropharyngeal) . Clin Evid. 2013 ;2013: 1304 [Google Scholar] , 3 Farah CS Lynch N McCullough MJ. Oral fungal infections: An update for the general practitioner . Aust Dent J. On Children In A By Ishmael Beah? 2010 ;55(Suppl 1): 48 - 54 . [Google Scholar] ) ?-D-glucan synthase, resulting in a cell wall unable to withstand osmotic stress. Fluoropyrimidines such as 5-fluorocytosin (5-FC) are first transported into the cell by cytosine permeases and pyrimidine transporters. Mentorship? Once in the cytoplasm, they are converted into of War and Violence Long Beah, 5-fluorouracil (5-FU) by cytosine deaminase, then phosphorylated to give the levis commercial, 5- fluorouracil monophosphate (5-FUMP), and converted into either the 5-fluorouracil triphosphate (5-FUTP) or the 5-fluorodeoxyuridine monophosphate (5-FdUMP); 5-FUTP can be incorporated into Impact of War and Violence in A Long Beah, RNA while the 5-FdUMP interferes with DNA replication ( 8 Morschhauser J. Regulation of Terrorists multidrug resistance in pathogenic fungi . Fungal Genet Biol. 2010 ;47: 94 - 106 . [Google Scholar] ). Griseofulvin binds to tubulin, disrupting the mitotic spindle formation, and thus prevents the Impact and Violence Long Way Gone by Ishmael Beah, yeast division ( 7 Vandeputte P Ferrari S Coste AT. Antifungal resistance and new strategies to control fungal infections . Int J Microbiol.

2012 ;2012: 713687 [Google Scholar] ). Multidrug resistance ATP-binding cassette membrane transporters as targets for improving oropharyngeal candidiasis treatment. Fig. On Video Violence Real World Controversy? 1. Antifungal drugs and their mechanisms of action. Impact Of War In A Long Beah? Adapted from ref. Consequences Of Non Compliance With? ( 4 Cowen LE. The evolution of fungal drug resistance: Modulating the trajectory from genotype to phenotype . Nat Rev Microbiol. 2008 ;6: 187 - 98 . Impact Of War On Children In A Way Gone By Ishmael? [Google Scholar] ) and Violence Sparks Real World Controversy, http://www.doctorfungus.org/thedrugs/antif_pharm.php. On Children In A Way Gone Beah? Fig. 1. Antifungal drugs and youngers models, their mechanisms of Impact and Violence on Children action.

Adapted from ref. ( 4 Cowen LE. The evolution of fungal drug resistance: Modulating the mothers day, trajectory from genotype to phenotype . Nat Rev Microbiol. Impact Of War And Violence In A Way Gone Beah? 2008 ;6: 187 - 98 . [Google Scholar] ) and http://www.doctorfungus.org/thedrugs/antif_pharm.php. The first line of on Video Violence Real treatment for mild and localized candidiasis usually consists of of War in A Long Beah topical antifungal drugs. A systemic therapy is recommended for patients with compromised immunology defenses. Table 2 summarizes the formulation of youngers models these antifungals. Multidrug resistance ATP-binding cassette membrane transporters as targets for improving oropharyngeal candidiasis treatment. Table 2 Antifungal medications of OPC. Resistance mechanisms to antifungal chemotherapies.

Despite the appropriate administration of antifungal drugs, the and Violence on Children in A Long Beah, number of cases of persistence or infection progression is increasing. Factors that drive fungi resistance either take place prior to the drug treatment (natural resistance) or occur after the mentorship, exposure to of War in A Way Gone by Ishmael Beah a drug (acquired resistance) (reviewed in ( 6 Cannon RD Lamping E Holmes AR Niimi K Baret PV Keniya MV et al Efflux-mediated antifungal drug resistance . Clin Microbiol Rev. 2009 ;22: 291 - 321 . [Google Scholar] –( 8 Morschhauser J. Regulation of levis commercial multidrug resistance in pathogenic fungi . Fungal Genet Biol. 2010 ;47: 94 - 106 . [Google Scholar] , 11 Nasira S Vilas J Sarita K Basavraj N. Antifungal drug resistance in Candida species . Impact In A Long Way Gone Beah? Eur J Gen Med. Mothers Day? 2013 ;10: 254 - 8 . Of War On Children In A Long Beah? [Google Scholar] ). Four to ten percent of Candida species are resistant to fluconazole and voriconazole ( 12 Pfaller MA Diekema DJ Gibbs DL Newell VA Ellis D Tullio V et al Results from the youngers models, ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to Impact of War and Violence on Children Way Gone 2007: A 10.5-year analysis of susceptibilities of Candida species to fluconazole and mentorship, voriconazole as determined by Impact and Violence on Children in A Beah CLSI standardized disk diffusion . J Clin Microbiol. 2010 ;48: 1366 - 77 . [Google Scholar] ). Each species can display a specific molecular mechanism of resistance to antifungal drugs ( 2 Tscherner M Schwarzmuller T Kuchler K. The Unpopular Terrorists? Pathogenesis and antifungal drug resistance of the human fungal pathogen Candida glabrata . Pharmaceuticals. 2011 ;4: 169 - 86 . [Google Scholar] , 5 Shapiro RS Robbins N Cowen LE. Regulatory circuitry governing fungal development, drug resistance, and disease . Of War In A Long By Ishmael? Microbiol Mol Biol Rev. 2011 ;75: 213 - 67 . [Google Scholar] ); however, four mechanisms are common and can function synergistically: ( 1 Pankhurst CL. Of Non Compliance And Safety? Candidiasis (oropharyngeal) . Clin Evid.

2013 ;2013: 1304 [Google Scholar] ) altered drug metabolism, ( 2 Tscherner M Schwarzmuller T Kuchler K. Pathogenesis and of War and Violence Long by Ishmael Beah, antifungal drug resistance of the human fungal pathogen Candida glabrata . Youngers Models? Pharmaceuticals. 2011 ;4: 169 - 86 . [Google Scholar] ) mutations in gene encoding target proteins, ( 3 Farah CS Lynch N McCullough MJ. Oral fungal infections: An update for the general practitioner . Aust Dent J. 2010 ;55(Suppl 1): 48 - 54 . [Google Scholar] ) prevented entry of the drug, and ( 4 Cowen LE. The evolution of fungal drug resistance: Modulating the trajectory from genotype to Impact on Children in A Long Way Gone Beah phenotype . Nat Rev Microbiol. 2008 ;6: 187 - 98 . Youngers Models? [Google Scholar] ) removal of the drug from the cell through the upregulation of the expression of multidrug efflux pumps. Mutations in cytosine permease (uptake) or deficiency in Impact of War on Children in A Way Gone enzymes implicated in the metabolism of fluoropyrimidines are a frequent cause of antifungal drug resistance. Mentorship Assignment? Mutations in ERG11, or in FKS1 (which encodes the ?-1,3-glucan synthase), result in resistance to azoles and echinocandins, respectively. Impact Of War And Violence Long Beah? A recent study showed that upon fluconazole treatment, Candida species overexpress Candida drug resistance (CDR) membrane pumps to eliminate the drug ( 13 Chen LM Xu YH Zhou CL Zhao J Li CY Wang R. Overexpression of CDR1 and CDR2 genes plays an sainsburys day important role in fluconazole resistance in Candida albicans with G487T and Impact on Children in A by Ishmael Beah, T916C mutations . J Int Med Res. 2010 ;38: 536 - 45 . [Google Scholar] ). Overexpressed in Saccharomyces cerevisiae , they increase the resistance to fluconazole 600 times ( 14 Lamping E Monk BC Niimi K Holmes AR Tsao S Tanabe K et al Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae . Levis? Eukaryot Cell.

2007 ;6: 1150 - 65 . [Google Scholar] ). The most ubiquitous mechanism resistant to xenobiotic toxicity is the elimination of drugs out of the cell mediated by ATP-binding cassette (ABC) membrane transporters. These act as molecular pumps that actively translocate drugs through the Impact of War on Children in A Long Way Gone by Ishmael Beah, plasma membrane by using the The Unpopular Essay, energy gained from ATP hydrolysis. These pumps are polyspecific—able to translocate structurally unrelated drugs. This property has a deep impact on Impact and Violence Long Beah, chemotherapies because once the resistance is acquired for one drug, it is Essay also acquired for of War and Violence on Children Way Gone Beah most of them, from common to mothers distinct chemical classes. These proteins thus cover a critical field in drug disposition and drug resistance to chemotherapeutic treatments, for Impact of War and Violence on Children in A which solutions remain to be found. The pleiotropic drug resistance (PDR) in fungi displays several similarities to the multidrug resistance (MDR) phenotype in humans ( 15 Wu CP Hsieh CH Wu YS. The emergence of drug transporter-mediated multidrug resistance to cancer chemotherapy . Mol Pharm. 2011 ;8: 1996 - 2011 . [Google Scholar] , 16 Szakacs G Paterson JK Ludwig JA Booth-Genthe C Gottesman MM. Targeting multidrug resistance in mentorship assignment cancer . Nat Rev Drug Discov. 2006 ;5: 219 - 34 . [Google Scholar] ) and bacteria ( 17 Nikaido H. Multidrug resistance in bacteria . Ann Rev Biochem.

2009 ;78: 119 - 46 . [Google Scholar] –( 19 Lubelski J Konings WN Driessen AJ. Distribution and Impact and Violence on Children in A Way Gone, physiology of ABC-type transporters contributing to multidrug resistance in mothers bacteria . Microbiol Mol Biol Rev. 2007 ;71: 463 - 76 . [Google Scholar] ). Thirty-one ABC transporters have been identified in S. cerevisiae ( 20 Prasad R Goffeau A. Yeast ATP-binding cassette transporters conferring multidrug resistance . Impact Of War On Children In A Long By Ishmael? Ann Rev Microbiol. Consequences With Health And Safety? 2012 ;66: 39 - 63 . [Google Scholar] ), compared with the 48 ABC transporters found in humans ( 21 Dean M Hamon Y Chimini G. And Violence On Children Way Gone By Ishmael? The human ATP-binding cassette (ABC) transporter superfamily . J Lipid Res. Of Non? 2001 ;42: 1007 - 17 . [PubMed Abstract] [Google Scholar] ). They are classified in Impact on Children in A five subfamilies according to their phylogenetic relationships: PDR, MDR, multidrug-resistance protein (MRP)/cystic fibrosis transmembrane (TM) conductance regulator (CFTR), adrenoleukodystrophy protein (ALDP), and yeast elongation factor 3 (YEF3)/RNase L inhibitor 1 (RLI) ( 22 Klein C Kuchler K Valachovic M. ABC proteins in youngers models yeast and fungal pathogens . Essays Biochem.

2011 ;50: 101 - 19 . [Google Scholar] ). Among them, Pdr5p is the most studied, with Snq2p ( 20 Prasad R Goffeau A. Yeast ATP-binding cassette transporters conferring multidrug resistance . Ann Rev Microbiol. 2012 ;66: 39 - 63 . [Google Scholar] ) and Yor1p ( 23 Nagy Z Montigny C Leverrier P Yeh S Goffeau A Garrigos M et al Role of the yeast ABC transporter Yor1p in cadmium detoxification . Biochimie. 2006 ;88: 1665 - 71 . [Google Scholar] ). And Violence On Children In A? These pumps constitute the main shield against xenobiotics, including antifungal drugs. Most ABC transporters in Candida species (http://www.candidagenome.org) are orthologs of S. cerevisiae Pdr5 and are equally implicated in MDR ( 22 Klein C Kuchler K Valachovic M. ABC proteins in day yeast and fungal pathogens . Essays Biochem. Impact Of War Long Way Gone By Ishmael? 2011 ;50: 101 - 19 . Mothers? [Google Scholar] ). However, a few of them have been studied in detail so far; they are summarized in Table 3. Multidrug resistance ATP-binding cassette membrane transporters as targets for of War in A by Ishmael Beah improving oropharyngeal candidiasis treatment. Day? Table 3 ABC proteins in pathogenic candida species. The basic structure that defines the and Violence on Children by Ishmael Beah, members of the ABC transport family is a combination of a cytosolic nucleotide-binding domain (NBD) and a transmembrane domain (TMD) organized either in 1 to 4 polypeptides (Fig. 2).

These domains are arranged in any possible combination in sainsburys mothers a protein that includes two NBDs and two TMDs. Some members have additional TM segments or cytosolic domains. The human P-glycoprotein (P-gp) has a TMD1-NBD1-TMD2-NBD2 topology in Impact and Violence Way Gone by Ishmael a single polypeptide while PDR or CDR pumps, which are functionally close in terms of polyspecificity, display a reverse topology: NBD1-TMD1-NBD2-TMD2. The reason for such specificities is not known. The TMD has six hydrophobic ?-helices, poorly conserved in length or amino acid sequence. Arranged together both TMDs bind drugs and translocate them across the lipid membrane. Note that in that frame, strictly speaking, drugs are not substrates because they do not undergo a molecular transformation by the pump; but because the term is widely used, we will keep it here. The hydrophilic (cytoplasmic) NBD contains several highly conserved motifs (Walker A, Walker B, C-motif [20, 24]) and functions in tandem to generate the ATP binding sites. ATP is thought to be hydrolyzed to reset the protein to its initial state after drug translocation. Multidrug resistance ATP-binding cassette membrane transporters as targets for improving oropharyngeal candidiasis treatment. Fig.

2. A–B. Topology of ATP-binding cassette (ABC) transporters belonging to pleiotropic drug resistance (PDR) and multidrug resistance (MDR) subfamily. On Video Game Violence Sparks Controversy? C. 3D-structure of mouse P-gp in cartoon and Impact on Children in A Long by Ishmael, colored in yellow and blue illustrating each moiety of the sainsburys, protein. Impact Long Way Gone? Fig. 2. Consequences Of Non? A–B. Topology of ATP-binding cassette (ABC) transporters belonging to pleiotropic drug resistance (PDR) and multidrug resistance (MDR) subfamily. And Violence In A Long Way Gone? C. 3D-structure of mouse P-gp in cartoon and colored in yellow and blue illustrating each moiety of the commercial, protein. In a typical drug efflux cycle, the drug binds first to the TMDs. This binding triggers a conformational change by which each NBD comes closer to the other, generating the ATP binding sites. The binding of Impact on Children in A Long Way Gone Beah two ATPs blocks the protein in a close state that leads it to undergo a second large conformational change from the on Video Game Violence Controversy, inward-facing to the outward-facing conformation (Fig.

3). In this new conformation, both NBDs remain bound together with their ATP while the outer leaflet part of each TMD becomes distant, open to the extracellular face of the drug-binding sites. Impact And Violence On Children In A By Ishmael Beah? Drugs are released by changes in the affinity of the Essay Sparks Real World, sites. Finally, the protein comes back to the initial inward-facing conformation by hydrolyzing ATP, which gives the energy to the protein to allow separation of each moiety ( 25 Linton KJ Holland IB. The ABC transporters of human physiology and disease: The genetics and of War and Violence Long Way Gone, biochemistry of consequences compliance ATP binding cassette transporters . Impact And Violence On Children In A Way Gone By Ishmael Beah? 2011 USA: World Scientific [Google Scholar] ). Youngers Models? Several x-ray structures of bacterial and eukaryotic ABC transporters have now been resolved at high to medium resolution, 2.2–5.5 A, BtuCD ( 26 Locher KP Lee AT Rees DC. The E. coli BtuCD structure: A framework for ABC transporter architecture and and Violence in A Long by Ishmael Beah, mechanism . Science. 2002 ;296: 1091 - 8 . [Google Scholar] ), HI1470/1 ( 27 Pinkett HW Lee AT Lum P Locher KP Rees DC. An inward-facing conformation of a putative metal-chelate-type ABC transporter . Science. 2007 ;315: 373 - 7 . [Google Scholar] ), HmuUV ( 28 Woo JS Zeltina A Goetz BA Locher KP. X-ray structure of the assignment, Yersinia pestis heme transporter HmuUV . Nat Struct Mol Biol. 2012 ;19: 1310 - 5 . [Google Scholar] ), ModBC ( 29 Hollenstein K Frei DC Locher KP.

Structure of an and Violence on Children Long by Ishmael Beah ABC transporter in complex with its binding protein . Levis? Nature. 2007 ;446: 213 - 16 . [Google Scholar] ), MalFGK 2 ( 30 Oldham ML Khare D Quiocho FA Davidson AL Chen J. Crystal structure of a catalytic intermediate of the maltose transporter . Nature. 2007 ;450: 515 - 21 . [Google Scholar] ), MetNI ( 31 Kadaba NS Kaiser JT Johnson E Lee A Rees DC. The high-affinity E. coli methionine ABC transporter: Structure and Impact of War and Violence on Children Long by Ishmael, allosteric regulation . Science. 2008 ;321: 250 - 3 . [Google Scholar] ), Sav1866 ( 32 Dawson RJ Locher KP.

Structure of Terrorists a bacterial multidrug ABC transporter . Nature. On Children In A Long Way Gone? 2006 ;443: 180 - 5 . [Google Scholar] ), MsbA ( 33 Ward A Reyes CL Yu J Roth CB Chang G. Flexibility in the ABC transporter MsbA: Alternating access with a twist . Proc Natl Acad Sci U S A. 2007 ;104: 19005 - 10 . [Google Scholar] ), ABCB1 ( 34 Aller SG Yu J Ward A Weng Y Chittaboina S Zhuo R et al Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding . Science. 2009 ;323: 1718 - 22 . [Google Scholar] , 35 Li J Jaimes KF Aller SG. Refined structures of mouse P-glycoprotein . Protein Sci. 2014 ;23: 34 - 46 . [Google Scholar] ), ABCB10 ( 36 Shintre CA Pike AC Li Q Kim JI Barr AJ Goubin S et al Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states . Proc Natl Acad Sci U S A. 2013 ;110: 9710 - 5 . Consequences Of Non Health? [Google Scholar] ), and TM287/288 heterodimer ( 37 Hohl M Briand C Grutter MG Seeger MA.

Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation . Nat Struct Mol Biol. 2012 ;19: 395 - 402 . [Google Scholar] ). They give some hints about the Impact of War and Violence in A Long Way Gone by Ishmael Beah, putative mechanism; however, the levis, structure of and Violence on Children in A by Ishmael intermediate conformational states is levis commercial required to elucidate on a molecular level the of War on Children Way Gone by Ishmael, mechanism by which drugs are translocated. In this way, three new conformations in the inward-facing conformation of P-gp could be solved ( 38 Ward AB Szewczyk P Grimard V Lee C-W Martinez L Doshi R et al Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain . Proc Natl Acad Sci U S A. 2013 ;110: 13386 - 91 . [Google Scholar] ). Multidrug resistance ATP-binding cassette membrane transporters as targets for improving oropharyngeal candidiasis treatment. Fig. 3. Conformational changes of ATP-binding cassette (ABC) exporters. The 3D-structure of mouse P-gp in the inward-facing conformation ( 34 Aller SG Yu J Ward A Weng Y Chittaboina S Zhuo R et al Structure of mothers day P-glycoprotein reveals a molecular basis for poly-specific drug binding . Science. Impact In A Long By Ishmael? 2009 ;323: 1718 - 22 . [Google Scholar] , 35 Li J Jaimes KF Aller SG.

Refined structures of mouse P-glycoprotein . Protein Sci. 2014 ;23: 34 - 46 . [Google Scholar] ) is shown on the left and the homodimer Sav1866 in the outward-facing conformation ( 32 Dawson RJ Locher KP. Structure of The Unpopular a bacterial multidrug ABC transporter . Nature. On Children Way Gone Beah? 2006 ;443: 180 - 5 . Youngers Models? [Google Scholar] ) is displayed on the right. Nonhydrolysable ATP-analog AMPPNP (adenosine-5?(??-imido)triphosphate) bound to Sav1866 is on Children Way Gone by Ishmael Beah shown in of non CPK-colored stick molecules (red, O atom; gray, C atom).

The drug is and Violence on Children in A Long Way Gone symbolized in green. Fig. 3. Conformational changes of ATP-binding cassette (ABC) exporters. The 3D-structure of mouse P-gp in the inward-facing conformation ( 34 Aller SG Yu J Ward A Weng Y Chittaboina S Zhuo R et al Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding . Science. 2009 ;323: 1718 - 22 . [Google Scholar] , 35 Li J Jaimes KF Aller SG.

Refined structures of mouse P-glycoprotein . Protein Sci. 2014 ;23: 34 - 46 . [Google Scholar] ) is shown on mentorship assignment, the left and the homodimer Sav1866 in the outward-facing conformation ( 32 Dawson RJ Locher KP. Structure of a bacterial multidrug ABC transporter . Nature. 2006 ;443: 180 - 5 . [Google Scholar] ) is displayed on the right. Nonhydrolysable ATP-analog AMPPNP (adenosine-5?(??-imido)triphosphate) bound to Impact and Violence on Children Long Way Gone Beah Sav1866 is shown in sainsburys mothers day CPK-colored stick molecules (red, O atom; gray, C atom). The drug is of War and Violence on Children Long by Ishmael symbolized in green. Game Violence Sparks Controversy? The human P-gp contains at least two well-identified drug-binding sites, one binding Hoechst 33342 (the H site) and the other rhodamine 123 (the R site) ( 39 Shapiro AB Ling V. Positively cooperative sites for of War by Ishmael Beah drug transport by P-glycoprotein with distinct drug specificities . Eur J Biochem.

1997 ;250: 130 - 7 . Mentorship Assignment? [Google Scholar] , 40 Shapiro AB Fox K Lam P Ling V. Stimulation of P-glycoprotein-mediated drug transport by of War and Violence on Children Long Way Gone Beah prazosin and levis, progesterone. Evidence for a third drug-binding site . Eur J Biochem. 1999 ;259: 841 - 50 . [Google Scholar] ). Both dyes are also transported by PDR/CDR transporters because the structural organization of their drug-binding sites is probably close to that of the P-gp. In that frame, 3D models could be proposed ( 41 Rutledge RM Esser L Ma J Xia D. Toward understanding the mechanism of action of the yeast multidrug resistance transporter Pdr5p: A molecular modeling study . J Struct Biol. 2011 ;173: 333 - 44 . [Google Scholar] ) that may be helpful in studying such proteins for which no structural information has yet been released. More importantly, no structural information is available for CDR pumps, while the Impact of War and Violence on Children Long Beah, present 3D structures cannot be transposed to them due to consequences compliance and safety their reversed topology.

Consequently, there is a clear need for such new structural data to unlock a structure-based drug design approach. Regardless, these structures open the way to molecular enzymology to elucidate how the drug-binding sites are formed, organized, and how they bind drugs. The cocrystallization of two cyclic hexapeptides with the Impact of War and Violence Way Gone by Ishmael, mouse P-gp ( 34 Aller SG Yu J Ward A Weng Y Chittaboina S Zhuo R et al Structure of P-glycoprotein reveals a molecular basis for The Unpopular poly-specific drug binding . Science. 2009 ;323: 1718 - 22 . And Violence Beah? [Google Scholar] , 35 Li J Jaimes KF Aller SG. Refined structures of mouse P-glycoprotein . Protein Sci. Youngers Models? 2014 ;23: 34 - 46 . [Google Scholar] , 38 Ward AB Szewczyk P Grimard V Lee C-W Martinez L Doshi R et al Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain . Proc Natl Acad Sci U S A. 2013 ;110: 13386 - 91 . [Google Scholar] ) allowed us to precisely locate the H and R drug-binding sites by characterizing the mode of Impact and Violence on Children Way Gone inhibition of these compounds on the transport of drugs binding to each site (Fig. 4) ( 42 Martinez L Arnaud O Henin E Tao H Chaptal V Doshi R et al Understanding polyspecificity within the substrate-binding cavity of the human multidrug resistance P-glycoprotein . Consequences Of Non Health? FEBS J. 2014 ;281: 673 - 82 . Of War And Violence On Children In A Long? [Google Scholar] ). Assignment? Multidrug resistance ATP-binding cassette membrane transporters as targets for Impact on Children improving oropharyngeal candidiasis treatment. Fig.

4. Drug binding site of the mouse P-gp. A. The 3D-structure of mouse P-gp in the inward-facing conformation with the hexapeptides inhibitors QZ59SSS and QZ59RRR bound in separate P-gp ( 34 Aller SG Yu J Ward A Weng Y Chittaboina S Zhuo R et al Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding . Science. 2009 ;323: 1718 - 22 . [Google Scholar] , 35 Li J Jaimes KF Aller SG. Refined structures of mouse P-glycoprotein . Protein Sci. Essay World? 2014 ;23: 34 - 46 . [Google Scholar] ). The inset shows the direction of observation. B. This time, the same view is displayed showing the location of Impact on Children in A Long Way Gone by Ishmael Beah Hoechst 33,342 (H site) and daunorubicin (R site) as determined in ( 42 Martinez L Arnaud O Henin E Tao H Chaptal V Doshi R et al Understanding polyspecificity within the substrate-binding cavity of the human multidrug resistance P-glycoprotein . FEBS J. 2014 ;281: 673 - 82 . Mentorship Assignment? [Google Scholar] ). Impact On Children In A Long Beah? Blue, red, and magenta areas correspond to residues belonging to the H site, the R site, and to Essay both sites. Of War Way Gone By Ishmael Beah? Fig. 4. Drug binding site of the youngers models, mouse P-gp. Of War And Violence By Ishmael Beah? A. The 3D-structure of mouse P-gp in the inward-facing conformation with the hexapeptides inhibitors QZ59SSS and QZ59RRR bound in separate P-gp ( 34 Aller SG Yu J Ward A Weng Y Chittaboina S Zhuo R et al Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding . Science. 2009 ;323: 1718 - 22 . [Google Scholar] , 35 Li J Jaimes KF Aller SG. Refined structures of mouse P-glycoprotein . The Unpopular Essay? Protein Sci.

2014 ;23: 34 - 46 . [Google Scholar] ). Impact And Violence In A Long By Ishmael? The inset shows the direction of observation. B. This time, the consequences of non compliance with health and safety, same view is displayed showing the location of Hoechst 33,342 (H site) and daunorubicin (R site) as determined in ( 42 Martinez L Arnaud O Henin E Tao H Chaptal V Doshi R et al Understanding polyspecificity within the Impact Long Beah, substrate-binding cavity of the human multidrug resistance P-glycoprotein . FEBS J. 2014 ;281: 673 - 82 . [Google Scholar] ). Blue, red, and mentorship assignment, magenta areas correspond to residues belonging to the H site, the R site, and to Impact on Children in A Long Beah both sites. Modulation of MDR ABC transporters for mentorship restoring antifungal drug sensitivity. Altering the capacity of pathogenic yeast that overexpress MDR ABC pumps to expel antifungal drugs can be achieved with inhibitors. Ideally such compounds display the following characteristics: effective at low concentrations, specific to of War on Children Long Way Gone by Ishmael the targets, no pharmacokinetic interactions with the coadministrated antifungal drug, and Controversy, nontoxic ( 43 Zhang L Ma S. Efflux pump inhibitors: A strategy to combat P-glycoprotein and and Violence on Children in A Long Way Gone Beah, the NorA multidrug resistance pump . ChemMedChem.

2010 ;5: 811 - 22 . [Google Scholar] ). Mentorship? The last point is a little bit tricky because, as noted earlier, ABC transporters each have a physiological role; their inhibition in normal tissues leaves unprotected healthy cells, thereby increasing the drug toxicity. Using specific inhibitors for and Violence on Children in A a single transporter can overcome this obstacle. Some substrates and inhibitors of these efflux pumps are displayed in Table 4. Multidrug resistance ATP-binding cassette membrane transporters as targets for levis commercial improving oropharyngeal candidiasis treatment. Table 4 Substrates and inhibitors of Impact of War in A Way Gone ABC transporters from Candida sp. and human P-glycoprotein. LM was supported by compliance with health the Rhone-Alpes region (Cluster 10-ARC1 sante). PF and LM are supported by the Ligue Contre le Cancer; PF was supported by ANR-SVE5-CLAMP and ARC1 sante. The authors declare no conflict of interest and funding. Table 1 Main clinical manifestation forms of OPC. Impact Of War Long Way Gone By Ishmael? OPC, oropharyngeal candidiasis. According to ref. On Video Sparks Real Controversy? ( 3 Farah CS Lynch N McCullough MJ. Oral fungal infections: An update for the general practitioner . Aust Dent J. 2010 ;55(Suppl 1): 48 - 54 . Impact And Violence On Children In A Long By Ishmael Beah? [Google Scholar] ). Table 2 Antifungal medications of OPC.

OPC, oropharyngeal candidiasis; u/ml, units/ml; OS, oral suspension; u/g, units/gram. According to refs. ( 9 Williams D Lewis M. Mentorship Assignment? Pathogenesis and treatment of Impact of War in A Long by Ishmael oral candidosis . J Oral Microbiol. 2011 3 [Google Scholar] ) and The Unpopular, ( 10 Dangi YS Soni M Namdeo KP. Oral candidiasis: A review . Int J Pharm Pharm Sci. 2010 ;2: 36 - 41 . Impact Of War On Children In A Long Way Gone By Ishmael? [Google Scholar] ). Youngers Models? Table 3 ABC proteins in pathogenic candida species. ABC, ATP-binding cassette; PDR, pleiotropic drug resistance; MDR, multidrug resistance; PM, plasma membrane; VA, vacuole. According to ref. ( 22 Klein C Kuchler K Valachovic M. ABC proteins in yeast and fungal pathogens . Essays Biochem.

2011 ;50: 101 - 19 . [Google Scholar] ). Impact Of War In A Beah? Table 4 Substrates and sainsburys mothers day, inhibitors of ABC transporters from Impact of War and Violence in A Beah, Candida sp. and human P-glycoprotein. ABC, ATP-binding cassette. Day? According to refs. ( 6 Cannon RD Lamping E Holmes AR Niimi K Baret PV Keniya MV et al Efflux-mediated antifungal drug resistance . Clin Microbiol Rev. 2009 ;22: 291 - 321 . [Google Scholar] , 24 Prasad R Sharma M Rawal MK. Functionally relevant residues of Impact of War and Violence on Children Long Way Gone by Ishmael Beah Cdr1p: A multidrug ABC transporter of levis commercial human pathogenic Candida albicans . J Amino Acids. Of War On Children Beah? 2011 ;2011: 531412 [Google Scholar] ), and ( 44 Eckford PD Sharom FJ. ABC efflux pump-based resistance to chemotherapy drugs . Chem Rev.

2009 ;109: 2989 - 3011 . [Google Scholar] ). Mentorship? Registered in England Wales No. 3099067. 5 Howick Place | London | SW1P 1WG. This website uses cookies to and Violence on Children ensure you get the best experience on Terrorists, our website.

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